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IML2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853363, updated on 11-Sep-2024

Summary

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Official Symbol
IML2
Primary source
SGD:S000003618
Locus tag
YJL082W
See related
AllianceGenome:SGD:S000003618; FungiDB:YJL082W; VEuPathDB:YJL082W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in cellular response to misfolded protein. Located in mitochondrial outer membrane and nucleus. Orthologous to several human genes including TTC39B (tetratricopeptide repeat domain 39B) and TTC39C (tetratricopeptide repeat domain 39C). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (281185..283380)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Aly2p Neighboring gene Tax4p Neighboring gene Arp4p Neighboring gene Scp160p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Lipid Droplets Are Essential for Efficient Clearance of Cytosolic Inclusion Bodies. Moldavski O, et al. Dev Cell, 2015 Jun 8. PMID 26004510
  2. Heterozygous mutations cause genetic instability in a yeast model of cancer evolution. Coelho MC, et al. Nature, 2019 Feb. PMID 30700905, Free PMC Article
  3. Interactomic study on interaction between lipid droplets and mitochondria. Pu J, et al. Protein Cell, 2011 Jun. PMID 21748599, Free PMC Article
  4. Proteomic analysis of the yeast mitochondrial outer membrane reveals accumulation of a subclass of preproteins. Zahedi RP, et al. Mol Biol Cell, 2006 Mar. PMID 16407407, Free PMC Article
  5. The RNA-binding protein Puf5 contributes to buffering of mRNA upon chromatin-mediated changes in nascent transcription. Kochan DZ, et al. J Cell Sci, 2021 Aug 1. PMID 34350963, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in cellular response to misfolded protein IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial outer membrane HDA PubMed 
located_in mitochondrion HDA PubMed 
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Iml2p
NP_012453.1
  • Protein required for clearance of inclusion bodies; localizes to the inclusion bodies formed under protein misfolding stress; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; IML2 has a paralog, YKR018C, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    281185..283380
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181515.1 → NP_012453.1  TPA: Iml2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012453.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A6ZPP2, D6VWA1, P47031
    UniProtKB/TrEMBL
    B3LQ30, B5VL95, C7GR31, D3UF60, G2WGT5, N1P8G1
    Conserved Domains (1) summary
    pfam10300
    Location:38 → 622
    DUF3808; Protein of unknown function (DUF3808)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P47031.1

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