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SAP185 Sap185p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853347, updated on 3-Nov-2024

Summary

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Official Symbol
SAP185
Official Full Name
Sap185p
Primary source
SGD:S000003634
Locus tag
YJL098W
See related
AllianceGenome:SGD:S000003634; FungiDB:YJL098W; VEuPathDB:YJL098W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable protein phosphatase regulator activity. Involved in G1/S transition of mitotic cell cycle and tRNA wobble uridine modification. Acts upstream of or within positive regulation of potassium ion export across plasma membrane. Is active in mitochondrion. Orthologous to several human genes including PPP6R1 (protein phosphatase 6 regulatory subunit 1) and PPP6R3 (protein phosphatase 6 regulatory subunit 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See SAP185 in Genome Data Viewer
Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (242082..245258)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene 1-phosphatidylinositol 4-kinase LSB6 Neighboring gene Chs6p Neighboring gene enoyl-CoA hydratase PHS1 Neighboring gene mitochondrial 54S ribosomal protein YmL49

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sit4p protein phosphatase is required for sensitivity of Saccharomyces cerevisiae to Kluyveromyces lactis zymocin. Jablonowski D, et al. Genetics, 2001 Dec. PMID 11779790, Free PMC Article
  2. TOR controls transcriptional and translational programs via Sap-Sit4 protein phosphatase signaling effectors. Rohde JR, et al. Mol Cell Biol, 2004 Oct. PMID 15367655, Free PMC Article
  3. Genomic and Targeted Approaches Unveil the Cell Membrane as a Major Target of the Antifungal Cytotoxin Amantelide A. Elsadek LA, et al. Chembiochem, 2021 May 14. PMID 33527693, Free PMC Article
  4. Genetic variants of TORC1 signaling pathway affect nitrogen consumption in Saccharomyces cerevisiae during alcoholic fermentation. Molinet J, et al. PLoS One, 2019. PMID 31348805, Free PMC Article
  5. The SAP, a new family of proteins, associate and function positively with the SIT4 phosphatase. Luke MM, et al. Mol Cell Biol, 1996 Jun. PMID 8649382, Free PMC Article

See all (70) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables protein phosphatase binding IEA
Inferred from Electronic Annotation
more info
  
enables protein phosphatase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G1/S transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of potassium ion export across plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of potassium ion export across plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA wobble uridine modification IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrion HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Sap185p
NP_012437.1
  • Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap190p; SAP185 has a paralog, SAP190, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    242082..245258
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181531.1 → NP_012437.1  TPA: Sap185p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012437.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VW86, P40856
    UniProtKB/TrEMBL
    B3LQ15, N1P0T1
    Conserved Domains (1) summary
    pfam04499
    Location:259 → 772
    SAPS; SIT4 phosphatase-associated protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40856.1

Gene LinkOut

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