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PHO86 Pho86p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853325, updated on 18-Sep-2024

Summary

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Official Symbol
PHO86
Official Full Name
Pho86p
Primary source
SGD:S000003653
Locus tag
YJL117W
See related
AllianceGenome:SGD:S000003653; FungiDB:YJL117W; VEuPathDB:YJL117W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables unfolded protein binding activity. Involved in endoplasmic reticulum to Golgi vesicle-mediated transport; protein folding; and regulation of phosphate transport. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See PHO86 in Genome Data Viewer
Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (192531..193466)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene ribulose-phosphate 3-epimerase RPE1 Neighboring gene uncharacterized protein Neighboring gene SUN family protein NCA3 Neighboring gene nucleosome assembly factor ASF1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Phosphate transporter mediated lipid accumulation in Saccharomyces cerevisiae under phosphate starvation conditions. James AW, et al. Bioresour Technol, 2014 Jan. PMID 24212129
  2. Pho86p, an endoplasmic reticulum (ER) resident protein in Saccharomyces cerevisiae, is required for ER exit of the high-affinity phosphate transporter Pho84p. Lau WT, et al. Proc Natl Acad Sci U S A, 2000 Feb 1. PMID 10655492, Free PMC Article
  3. A putative new membrane protein, Pho86p, in the inorganic phosphate uptake system of Saccharomyces cerevisiae. Yompakdee C, et al. Gene, 1996 May 24. PMID 8675028
  4. Two new genes, PHO86 and PHO87, involved in inorganic phosphate uptake in Saccharomyces cerevisiae. Bun-ya M, et al. Curr Genet, 1996 Mar. PMID 8598055
  5. A genome-wide screen identifies yeast genes required for protection against or enhanced cytotoxicity of the antimalarial drug quinine. Dos Santos SC, et al. Mol Genet Genomics, 2011 Dec. PMID 21960436

See all (61) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables unfolded protein binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phosphate ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein folding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of phosphate transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Pho86p
NP_012418.1
  • Endoplasmic reticulum (ER) resident protein; required for ER exit of the high-affinity phosphate transporter Pho84p, specifically required for packaging of Pho84p into COPII vesicles; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    192531..193466
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181550.1 → NP_012418.1  TPA: Pho86p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012418.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VW67, E9P8T7, P46956
    UniProtKB/TrEMBL
    A6ZQL2, B3LQ00, B5VL58, C7GQ09, C8ZBA2, G2WGQ4, N1P0K1
    Conserved Domains (1) summary
    pfam11124
    Location:23 → 302
    Pho86; Inorganic phosphate transporter Pho86
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P46956.1

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