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GCD14 tRNA 1-methyladenosine methyltransferase subunit GCD14 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853317, updated on 2-Nov-2024

Summary

Official Symbol
GCD14
Official Full Name
tRNA 1-methyladenosine methyltransferase subunit GCD14
Primary source
SGD:S000003661
Locus tag
YJL125C
See related
AllianceGenome:SGD:S000003661; FungiDB:YJL125C; VEuPathDB:YJL125C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
TRM61
Summary
Contributes to tRNA (adenine(58)-N1)-methyltransferase activity. Involved in tRNA methylation. Located in nucleus. Part of tRNA (m1A) methyltransferase complex. Orthologous to human TRMT61A (tRNA methyltransferase 61A). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

See GCD14 in Genome Data Viewer
Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (185528..186679, complement)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Spt10p Neighboring gene putative hydrolase Neighboring gene Lsm1p Neighboring gene Mtc1p

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Process Evidence Code Pubs
involved_in methylation IEA
Inferred from Electronic Annotation
more info
 
involved_in tRNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in tRNA methylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in tRNA methylation IEA
Inferred from Electronic Annotation
more info
 
involved_in tRNA processing IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of tRNA (m1A) methyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of tRNA (m1A) methyltransferase complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of tRNA (m1A) methyltransferase complex IEA
Inferred from Electronic Annotation
more info
 
part_of tRNA (m1A) methyltransferase complex IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
tRNA 1-methyladenosine methyltransferase subunit GCD14
NP_012410.1
  • Subunit of tRNA (1-methyladenosine) methyltransferase; required, along with Gcd10p, for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    185528..186679 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181558.1NP_012410.1  TPA: tRNA 1-methyladenosine methyltransferase subunit GCD14 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012410.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VW61, P46959
    UniProtKB/TrEMBL
    G2WGP8, N1P1K0
    Conserved Domains (1) summary
    COG2519
    Location:12291
    Gcd14; tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]