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ATP12 ATP synthase complex assembly protein ATP12 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853259, updated on 18-Sep-2024

Summary

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Official Symbol
ATP12
Official Full Name
ATP synthase complex assembly protein ATP12
Primary source
SGD:S000003716
Locus tag
YJL180C
See related
AllianceGenome:SGD:S000003716; FungiDB:YJL180C; VEuPathDB:YJL180C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables protein domain specific binding activity. Involved in mitochondrial proton-transporting ATP synthase complex assembly. Located in mitochondrion. Used to study mitochondrial complex V (ATP synthase) deficiency, nuclear type 1. Human ortholog(s) of this gene implicated in mitochondrial complex V (ATP synthase) deficiency, nuclear type 1. Orthologous to human ATPAF2 (ATP synthase mitochondrial F1 complex assembly factor 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See ATP12 in Genome Data Viewer
Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (87583..88560, complement)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene alpha-1,6-mannosyltransferase Neighboring gene Rbh1p Neighboring gene prefolding complex chaperone subunit Neighboring gene Atg27p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mutational studies with Atp12p, a protein required for assembly of the mitochondrial F1-ATPase in yeast. Identification of domains important for Atp12p function and oligomerization. Wang ZG, et al. J Biol Chem, 1998 Jan 30. PMID 9446613
  2. Respiratory chain complex V deficiency due to a mutation in the assembly gene ATP12. De Meirleir L, et al. J Med Genet, 2004 Feb. PMID 14757859, Free PMC Article
  3. Defining the pathogenesis of the human Atp12p W94R mutation using a Saccharomyces cerevisiae yeast model. Meulemans A, et al. J Biol Chem, 2010 Feb 5. PMID 19933271, Free PMC Article
  4. Identification of a nuclear gene (FMC1) required for the assembly/stability of yeast mitochondrial F(1)-ATPase in heat stress conditions. Lefebvre-Legendre L, et al. J Biol Chem, 2001 Mar 2. PMID 11096112
  5. Mitochondrial DNA mutations provoke dominant inhibition of mitochondrial inner membrane fusion. Sauvanet C, et al. PLoS One, 2012. PMID 23166736, Free PMC Article

See all (52) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that wild type human Atp12p rescues the respiratory defect of a yeast ATP12 deletion mutant (Deltaatp12).
    Title: Defining the pathogenesis of the human Atp12p W94R mutation using a Saccharomyces cerevisiae yeast model.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables protein domain specific binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in mitochondrial proton-transporting ATP synthase complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial proton-transporting ATP synthase complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrial proton-transporting ATP synthase complex assembly IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in proton-transporting ATP synthase complex assembly IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial intermembrane space IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ATP synthase complex assembly protein ATP12
NP_012355.1
  • Assembly factor for F1 sector of mitochondrial F1F0 ATP synthase; conserved protein; required for assembly of alpha and beta subunits into F1 sector of mitochondrial F1F0 ATP synthase; human homolog ATPAF2 can complement yeast atp12 mutant; mutation of human homolog reduces active ATP synthase levels and is associated with the disorder ATPAF2 deficiency

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    87583..88560 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181613.1 → NP_012355.1  TPA: ATP synthase complex assembly protein ATP12 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012355.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VW09, P22135
    UniProtKB/TrEMBL
    A6ZQF4, B3LPU5, B5VL10, C7GS06, C8ZB39, G2WGJ5, N1P0D8
    Conserved Domains (1) summary
    COG5387
    Location:18 → 325
    Atp12; Chaperone required for the assembly of the mitochondrial F1-ATPase [Posttranslational modification, protein turnover, chaperones]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P22135.2

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