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MNN11 alpha-1,6-mannosyltransferase [ Saccharomyces cerevisiae S288C ]

Gene ID: 853256, updated on 18-Sep-2024

Summary

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Official Symbol
MNN11
Official Full Name
alpha-1,6-mannosyltransferase
Primary source
SGD:S000003719
Locus tag
YJL183W
See related
AllianceGenome:SGD:S000003719; FungiDB:YJL183W; VEuPathDB:YJL183W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables alpha-1,6-mannosyltransferase activity. Involved in protein N-linked glycosylation. Located in endoplasmic reticulum. Part of mannan polymerase complex. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See MNN11 in Genome Data Viewer
Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (84068..85336)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Atg36p Neighboring gene chromatin DNA-binding EKC/KEOPS complex subunit GON7 Neighboring gene Rbh1p Neighboring gene ATP synthase complex assembly protein ATP12

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Disruption of the MNN10 gene enhances protein secretion in Kluyveromyces lactis and Saccharomyces cerevisiae. Bartkeviciūte D, et al. FEMS Yeast Res, 2004 Sep. PMID 15450190
  2. Multi-protein complexes in the cis Golgi of Saccharomyces cerevisiae with alpha-1,6-mannosyltransferase activity. Jungmann J, et al. EMBO J, 1998 Jan 15. PMID 9430634, Free PMC Article
  3. Quantitative proteomics reveals a Gα/MAPK signaling hub that controls pheromone-induced cellular polarization in yeast. Waszczak N, et al. J Proteomics, 2019 Sep 15. PMID 31351147
  4. Proper protein glycosylation promotes mitogen-activated protein kinase signal fidelity. Lien EC, et al. Biochemistry, 2013 Jan 8. PMID 23210626, Free PMC Article
  5. Interaction among the subunits of Golgi membrane mannosyltransferase complexes of the yeast Saccharomyces cerevisiae. Kojima H, et al. Biosci Biotechnol Biochem, 1999 Nov. PMID 10635561

See all (69) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables alpha-1,6-mannosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha-1,6-mannosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein N-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein N-linked glycosylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein glycosylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein glycosylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum HDA PubMed 
part_of mannan polymerase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mannan polymerase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
alpha-1,6-mannosyltransferase
NP_012352.2
  • Subunit of a Golgi mannosyltransferase complex; this complex also contains Anp1p, Mnn9p, Mnn10p, and Hoc1p, and mediates elongation of the polysaccharide mannan backbone; has homology to Mnn10p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    84068..85336
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181616.2 → NP_012352.2  TPA: alpha-1,6-mannosyltransferase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012352.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VW07, E9P8Z0, P46985
    UniProtKB/TrEMBL
    A6ZQF2, B3LPU3, B5VL08, C8ZB36, G2WGJ3, N1P3S7
    Conserved Domains (1) summary
    pfam05637
    Location:156 → 408
    Glyco_transf_34; galactosyl transferase GMA12/MNN10 family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P46985.2

Gene LinkOut

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