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PHO90 SPX domain-containing inorganic phosphate transporter [ Saccharomyces cerevisiae S288C ]

Gene ID: 853241, updated on 2-Nov-2024

Summary

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Official Symbol
PHO90
Official Full Name
SPX domain-containing inorganic phosphate transporter
Primary source
SGD:S000003734
Locus tag
YJL198W
See related
AllianceGenome:SGD:S000003734; FungiDB:YJL198W; VEuPathDB:YJL198W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables phosphate transmembrane transporter activity. Involved in phosphate ion transport; polyphosphate metabolic process; and regulation of phosphate transmembrane transport. Located in plasma membrane. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 25. Orthologous to several human genes including SLC13A1 (solute carrier family 13 member 1); SLC13A2 (solute carrier family 13 member 2); and SLC13A4 (solute carrier family 13 member 4). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See PHO90 in Genome Data Viewer
Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (60844..63489)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene tRNA-Thr Neighboring gene Mbb1p Neighboring gene putative ubiquitin-specific protease UBP12 Neighboring gene fatty acid elongase ELO1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Complementary structures of the yeast phosphate transporter Pho90 provide insights into its transport mechanism. Schneider S, et al. Structure, 2024 Jul 11. PMID 38688287
  2. Budding yeast escape commitment to the phosphate starvation program using gene expression noise. Vardi N, et al. Curr Biol, 2013 Oct 21. PMID 24094854
  3. The SPX domain of the yeast low-affinity phosphate transporter Pho90 regulates transport activity. Hürlimann HC, et al. EMBO Rep, 2009 Sep. PMID 19590579, Free PMC Article
  4. Transcriptional regulation of phosphate-responsive genes in low-affinity phosphate-transporter-defective mutants in Saccharomyces cerevisiae. Auesukaree C, et al. Biochem Biophys Res Commun, 2003 Jul 11. PMID 12821119
  5. Inhibition of the protein kinase A alters the degradation of the high-affinity phosphate transporter Pho84 in Saccharomyces cerevisiae. Mouillon JM, et al. Curr Genet, 2005 Oct. PMID 16160831

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Complementary structures of the yeast phosphate transporter Pho90 provide insights into its transport mechanism.
    Title: Complementary structures of the yeast phosphate transporter Pho90 provide insights into its transport mechanism.
  2. Pho90 represent non-redundant P(i) transporters, which are tuned by the integration of multiple nutrient signalling mechanisms in order to adjust P(i)-transport capacity to the general nutritional status of the environment.
    Title: Differential roles for the low-affinity phosphate transporters Pho87 and Pho90 in Saccharomyces cerevisiae.
  3. SPX domain of Pho90 limits the phosphate-uptake velocity, suppresses phosphate efflux and affects the regulation of the phosphate signal transduction pathway.
    Title: The SPX domain of the yeast low-affinity phosphate transporter Pho90 regulates transport activity.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables phosphate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphate transmembrane transporter activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables phosphate transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in phosphate ion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphate ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphate ion transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in polyphosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in polyphosphate metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of phosphate transmembrane transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell periphery HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
SPX domain-containing inorganic phosphate transporter
NP_012337.1
  • Low-affinity phosphate transporter; acts upstream of Pho81p in regulation of the PHO pathway; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth; PHO90 has a paralog, PHO87, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    60844..63489
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181631.1 → NP_012337.1  TPA: SPX domain-containing inorganic phosphate transporter [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012337.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P39535
    UniProtKB/TrEMBL
    G2WGI0
    Conserved Domains (2) summary
    COG5408
    Location:1 → 288
    COG5408; SPX domain-containing protein [Signal transduction mechanisms]
    cd01115
    Location:442 → 870
    SLC13_permease; Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P39535.1

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