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OPT1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853218, updated on 11-Sep-2024

Summary

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Official Symbol
OPT1
Primary source
SGD:S000003748
Locus tag
YJL212C
See related
AllianceGenome:SGD:S000003748; FungiDB:YJL212C; VEuPathDB:YJL212C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
DUG4; GSH11; HGT1
Summary
Enables proton-dependent oligopeptide secondary active transmembrane transporter activity. Involved in oligopeptide transport. Is integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (33850..36249, complement)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene hexose transporter HXT8 Neighboring gene uncharacterized protein Neighboring gene ubiquitin-protein ligase peroxin 2 Neighboring gene Cbp1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of residues critical for proton-coupled glutathione translocation in the yeast glutathione transporter, Hgt1p. Zulkifli M, et al. Biochem J, 2017 May 16. PMID 28389436
  2. Substrate specificity and mapping of residues critical for transport in the high-affinity glutathione transporter Hgt1p. Zulkifli M, et al. Biochem J, 2016 Aug 1. PMID 27252386
  3. Charged/Polar-residue scanning of the hydrophobic face of transmembrane domain 9 of the yeast glutathione transporter, hgt1p, reveals a conformationally critical region for substrate transport. Thakur A, et al. G3 (Bethesda), 2015 Mar 16. PMID 25784163, Free PMC Article
  4. The role of transmembrane domain 9 in substrate recognition by the fungal high-affinity glutathione transporters. Thakur A, et al. Biochem J, 2010 Aug 1. PMID 20477749
  5. Gln-222 in transmembrane domain 4 and Gln-526 in transmembrane domain 9 are critical for substrate recognition in the yeast high affinity glutathione transporter, Hgt1p. Kaur J, et al. J Biol Chem, 2009 Aug 28. PMID 19589778, Free PMC Article

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data suggest that protonated residues E/D135 or N710 in Hgt1p prevent substrate/glutathione from binding at high pH; mutation of these residues allows substrate/glutathione to bind in a proton-dependent manner through involvement of other residues.
    Title: Identification of residues critical for proton-coupled glutathione translocation in the yeast glutathione transporter, Hgt1p.
  2. The cysteine-free Hgt1p was nonfunctional and pointed to a critical role being played by the native cysteine residues of Hgt1p.
    Title: Differential roles played by the native cysteine residues of the yeast glutathione transporter, Hgt1p.
  3. Asn-124 in transmembrane domain 1(TMD1), Gln-222 in TMD4, Gln-526 in TMD9, and Glu-544, Arg-554, and Lys-562 in the intracellular loop are essential for the transport activity of Hgt1.
    Title: Gln-222 in transmembrane domain 4 and Gln-526 in transmembrane domain 9 are critical for substrate recognition in the yeast high affinity glutathione transporter, Hgt1p.
  4. ScOPT1 and AtOPT4 are proton-coupled OPTs with broad but distinct substrate specificities and affinities.
    Title: ScOPT1 and AtOPT4 function as proton-coupled oligopeptide transporters with broad but distinct substrate specificities.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables oligopeptide transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oligopeptide transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables oligopeptide transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in oligopeptide transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in oligopeptide transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in peptide transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
oligopeptide transporter OPT1
NP_012323.1
  • Proton-coupled oligopeptide transporter of the plasma membrane; also transports glutathione and phytochelatin; member of the OPT family

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    33850..36249 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181645.1 → NP_012323.1  TPA: oligopeptide transporter OPT1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012323.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VVY3, P40897
    UniProtKB/TrEMBL
    A6ZQC8, C8ZB08
    Conserved Domains (1) summary
    TIGR00728
    Location:88 → 760
    OPT_sfam; oligopeptide transporter, OPT superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40897.1

Gene LinkOut

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