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CWC22 U2-type spliceosomal complex subunit CWC22 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853195, updated on 2-Nov-2024

Summary

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Official Symbol
CWC22
Official Full Name
U2-type spliceosomal complex subunit CWC22
Primary source
SGD:S000003510
Locus tag
YGR278W
See related
AllianceGenome:SGD:S000003510; FungiDB:YGR278W; VEuPathDB:YGR278W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable RNA binding activity. Involved in mRNA splicing, via spliceosome. Part of U2-type spliceosomal complex. Orthologous to human CWC22 (CWC22 spliceosome associated protein homolog). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See CWC22 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (1046731..1048464)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Rnh70p Neighboring gene putative pantetheine-phosphate adenylyltransferase Neighboring gene putative family 17 glucosidase Neighboring gene telomerase inhibitor

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Postcatalytic spliceosome structure reveals mechanism of 3'-splice site selection. Wilkinson ME, et al. Science, 2017 Dec 8. PMID 29146871, Free PMC Article
  2. Molecular architecture of the Saccharomyces cerevisiae activated spliceosome. Rauhut R, et al. Science, 2016 Sep 23. PMID 27562955
  3. Splicing factor Cwc22 is required for the function of Prp2 and for the spliceosome to escape from a futile pathway. Yeh TC, et al. Mol Cell Biol, 2011 Jan. PMID 20956557, Free PMC Article
  4. Decrypting the Information Exchange Pathways across the Spliceosome Machinery. Saltalamacchia A, et al. J Am Chem Soc, 2020 May 6. PMID 32275149, Free PMC Article
  5. A nuclear proteome localization screen reveals the exquisite specificity of Gpn2 in RNA polymerase biogenesis. Minaker SW, et al. Cell Cycle, 2021 Jul. PMID 34180355, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In the absence of Cwc22, Prp2 can bind to the spliceosome but is dissociated upon ATP hydrolysis without promoting the release of SF3a/b.
    Title: Splicing factor Cwc22 is required for the function of Prp2 and for the spliceosome to escape from a futile pathway.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA splicing, via spliceosome IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of U2-type spliceosomal complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
U2-type spliceosomal complex subunit CWC22
NP_011794.3
  • Spliceosome-associated protein that is required for pre-mRNA splicing; necessary for Prp2p function at the first catalytic step of splicing; has similarity to S. pombe Cwf22p; CWC22 is an essential protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    1046731..1048464
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181407.3 → NP_011794.3  TPA: U2-type spliceosomal complex subunit CWC22 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011794.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VV55, P53333
    UniProtKB/TrEMBL
    A6ZUT4, G2WF01, N1P6A5
    Conserved Domains (2) summary
    smart00543
    Location:24 → 204
    MIF4G; Middle domain of eukaryotic initiation factor 4G (eIF4G)
    pfam02847
    Location:291 → 398
    MA3; MA3 domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53333.1

Gene LinkOut

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