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SDA1 Sda1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853160, updated on 7-Jul-2024

Summary

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Gene symbol
SDA1
Gene description
Sda1p
Primary source
FungiDB:YGR245C
Locus tag
YGR245C
See related
SGD:S000003477; AllianceGenome:SGD:S000003477; VEuPathDB:YGR245C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in ribosomal large subunit biogenesis; ribosomal large subunit export from nucleus; and traversing start control point of mitotic cell cycle. Located in nucleus. Orthologous to human SDAD1 (SDA1 domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See SDA1 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (979765..982068, complement)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene mitochondrial pyruvate carrier Neighboring gene succinate--CoA ligase (GDP-forming) subunit beta Neighboring gene transcription factor TFIIIB subunit BRF1 Neighboring gene 2',3'-cyclic-nucleotide 3'-phosphodiesterase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Expression and localization studies of hSDA, the human ortholog of the yeast SDA1 gene. Babbio F, et al. Cell Cycle, 2004 Apr. PMID 14976432
  2. The Saccharomyces cerevisiae SDA1 gene is required for actin cytoskeleton organization and cell cycle progression. Buscemi G, et al. J Cell Sci, 2000 Apr. PMID 10704371
  3. The Sda1 protein is required for passage through start. Zimmerman ZA, et al. Mol Biol Cell, 2001 Jan. PMID 11160833, Free PMC Article
  4. The yeast kinase Swe1 is required for proper entry into cell cycle after arrest due to ribosome biogenesis and protein synthesis defects. Saracino F, et al. Cell Cycle, 2004 May. PMID 15107621
  5. A pre-ribosome with a tadpole-like structure functions in ATP-dependent maturation of 60S subunits. Nissan TA, et al. Mol Cell, 2004 Jul 23. PMID 15260980

See all (65) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in ribosomal large subunit biogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ribosomal large subunit biogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in ribosomal large subunit biogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosomal large subunit export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ribosomal large subunit export from nucleus IEA
Inferred from Electronic Annotation
more info
  
involved_in ribosomal large subunit export from nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in traversing start control point of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Sda1p
NP_011761.3
  • Protein required for actin organization and passage through Start; highly conserved nuclear protein; required for actin cytoskeleton organization; plays a critical role in G1 events; binds Nap1p; involved in 60S ribosome biogenesis

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    979765..982068 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181374.3 → NP_011761.3  TPA: Sda1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011761.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VV25, P53313
    UniProtKB/TrEMBL
    A0A6A5Q1C8, A6ZUQ3, B3LHZ5, C7GNI4, C8Z9D7, G2WEX1, N1P2M8
    Conserved Domains (2) summary
    pfam05285
    Location:459 → 765
    SDA1
    pfam08158
    Location:93 → 142
    NUC130_3NT; NUC130/3NT domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53313.1

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