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YAP1802 Yap1802p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853157, updated on 18-Sep-2024

Summary

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Official Symbol
YAP1802
Official Full Name
Yap1802p
Primary source
SGD:S000003473
Locus tag
YGR241C
See related
AllianceGenome:SGD:S000003473; FungiDB:YGR241C; VEuPathDB:YGR241C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable SNARE binding activity; clathrin heavy chain binding activity; and phosphatidylinositol binding activity. Involved in endocytosis. Located in cellular bud neck; cytosol; and prospore membrane. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human PICALM (phosphatidylinositol binding clathrin assembly protein) and SNAP91 (synaptosome associated protein 91). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See YAP1802 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (974875..976581, complement)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene 6-phosphofructokinase subunit alpha Neighboring gene uncharacterized protein Neighboring gene mitochondrial pyruvate carrier Neighboring gene succinate--CoA ligase (GDP-forming) subunit beta

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Epsins: adaptors in endocytosis? Wendland B. Nat Rev Mol Cell Biol, 2002 Dec. PMID 12461563
  2. Role of Scd5, a protein phosphatase-1 targeting protein, in phosphoregulation of Sla1 during endocytosis. Chi RJ, et al. J Cell Sci, 2012 Oct 15. PMID 22825870, Free PMC Article
  3. The function of yeast epsin and Ede1 ubiquitin-binding domains during receptor internalization. Dores MR, et al. Traffic, 2010 Jan. PMID 19903324, Free PMC Article
  4. Interaction between Epsin/Yap180 adaptors and the scaffolds Ede1/Pan1 is required for endocytosis. Maldonado-Báez L, et al. Mol Biol Cell, 2008 Jul. PMID 18448668, Free PMC Article
  5. The Sla2p talin domain plays a role in endocytosis in Saccharomyces cerevisiae. Baggett JJ, et al. Genetics, 2003 Dec. PMID 14704157, Free PMC Article

See all (53) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables 1-phosphatidylinositol binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 1-phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
  
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables clathrin binding IEA
Inferred from Electronic Annotation
more info
  
enables clathrin binding TAS
Traceable Author Statement
more info
 PubMed 
enables clathrin heavy chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-4,5-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in clathrin coat assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in clathrin-dependent endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in clathrin-dependent endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in endocytosis IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in vesicle budding from membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cellular bud IEA
Inferred from Electronic Annotation
more info
  
located_in cellular bud neck HDA PubMed 
located_in cellular bud neck IEA
Inferred from Electronic Annotation
more info
  
is_active_in clathrin-coated pit IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in clathrin-coated vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in clathrin-coated vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol HDA PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in prospore membrane HDA PubMed 

General protein information

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Preferred Names
Yap1802p
NP_011757.3
  • Protein of the AP180 family, involved in clathrin cage assembly; binds Pan1p and clathrin; YAP1802 has a paralog, YAP1801, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    974875..976581 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181370.3 → NP_011757.3  TPA: Yap1802p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011757.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VV22, P53309
    UniProtKB/TrEMBL
    A6ZUQ0, C8Z9D3, N1P9Z0
    Conserved Domains (1) summary
    pfam07651
    Location:5 → 263
    ANTH; ANTH domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53309.1

Gene LinkOut

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