U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

PET54 Pet54p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853137, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
PET54
Official Full Name
Pet54p
Primary source
SGD:S000003454
Locus tag
YGR222W
See related
AllianceGenome:SGD:S000003454; FungiDB:YGR222W; VEuPathDB:YGR222W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables mRNA 5'-UTR binding activity; pre-mRNA intronic binding activity; and translation regulator activity. Involved in Group I intron splicing; mitochondrial mRNA processing; and positive regulation of mitochondrial translation. Located in mitochondrial inner membrane and mitochondrial matrix. [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See PET54 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (939923..940804)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Tos2p Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Hsv2p Neighboring gene azole transporter

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Characterization of mRNAs and coding potential of the PET54 gene from Saccharomyces cerevisiae. Burke KA, et al. Biochem Int, 1991 Sep. PMID 1724152
  2. Genetic evidence that different functional domains of the PET54 gene product facilitate expression of the mitochondrial genes COX1 and COX3 in Saccharomyces cerevisiae. Valencik ML, et al. Mol Cell Biol, 1991 May. PMID 1850094, Free PMC Article
  3. The PET54 gene of Saccharomyces cerevisiae: characterization of a nuclear gene encoding a mitochondrial translational activator and subcellular localization of its product. Costanzo MC, et al. Genetics, 1989 Jun. PMID 2548921, Free PMC Article
  4. A point mutation in the 5'-untranslated leader that affects translational activation of the mitochondrial COX3 mRNA. Costanzo MC, et al. Curr Genet, 1995 Jun. PMID 8536314
  5. Mitochondrial protein synthesis is not required for efficient excision of intron aI5 beta from COX1 pre-mRNA in Saccharomyces cerevisiae. Johnson CH, et al. Mol Gen Genet, 1997 Sep. PMID 9341683

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Pet54 physically interacts with the COX1 mRNA, and this binding was independent of the presence of Mss51.
    Title: A Novel Function of Pet54 in Regulation of Cox1 Synthesis in Saccharomyces cerevisiae Mitochondria.
  2. Competition experiments show that the COX3 5'UTL and aI5beta intron RNAs bind to the same or overlapping surface on Pet54p.
    Title: A shared RNA-binding site in the Pet54 protein is required for translational activation and group I intron splicing in yeast mitochondria.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA 5'-UTR binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables pre-mRNA intronic binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables translation regulator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in Group I intron splicing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in Group I intron splicing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial mRNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of mitochondrial translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Pet54p
NP_011738.3
  • Mitochondrial inner membrane protein; binds to the 5' UTR of the COX3 mRNA to activate its translation together with Pet122p and Pet494p; also binds to the COX1 Group I intron AI5 beta to facilitate exon ligation during splicing; also stimulates efficient synthesis of Cox1p

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    939923..940804
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181351.3 → NP_011738.3  TPA: Pet54p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011738.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VV04, P10834
    UniProtKB/TrEMBL
    A6ZUN2, B3LI16, B5VJG1, C8Z9B4, G2WEV0, N1P9Y6
    Conserved Domains (1) summary
    smart00361
    Location:211 → 270
    RRM_1; RNA recognition motif
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P10834.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools