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ZPR1 zinc finger-containing protein ZPR1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853125, updated on 18-Sep-2024

Summary

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Official Symbol
ZPR1
Official Full Name
zinc finger-containing protein ZPR1
Primary source
SGD:S000003443
Locus tag
YGR211W
See related
AllianceGenome:SGD:S000003443; FungiDB:YGR211W; VEuPathDB:YGR211W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable zinc ion binding activity. Involved in G2/M transition of mitotic cell cycle and cellular response to starvation. Located in cytoplasm and nucleus. Orthologous to human ZPR1 (ZPR1 zinc finger). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See ZPR1 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (915241..916701)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene thioredoxin TRX2 Neighboring gene uncharacterized protein Neighboring gene N-acetyltransferase Neighboring gene Rta1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structural insights into the interaction of the evolutionarily conserved ZPR1 domain tandem with eukaryotic EF1A, receptors, and SMN complexes. Mishra AK, et al. Proc Natl Acad Sci U S A, 2007 Aug 28. PMID 17704259, Free PMC Article
  2. The cytoplasmic zinc finger protein ZPR1 accumulates in the nucleolus of proliferating cells. Galcheva-Gargova Z, et al. Mol Biol Cell, 1998 Oct. PMID 9763455, Free PMC Article
  3. Cyclophilin A peptidyl-prolyl isomerase activity promotes ZPR1 nuclear export. Ansari H, et al. Mol Cell Biol, 2002 Oct. PMID 12242280, Free PMC Article
  4. Ubiquitin Linkage Specificity of Deubiquitinases Determines Cyclophilin Nuclear Localization and Degradation. Li Y, et al. iScience, 2020 Apr 24. PMID 32240951, Free PMC Article
  5. Interaction of ZPR1 with translation elongation factor-1alpha in proliferating cells. Gangwani L, et al. J Cell Biol, 1998 Dec 14. PMID 9852145, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein folding chaperone IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables translation elongation factor binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in 'de novo' protein folding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in G2/M transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger-containing protein ZPR1
NP_011727.3
  • Chaperone with two zinc fingers essential for eEF1A biogenesis; nuclear in growing cells, cytoplasmic in starved cells; shuttled via process mediated by Cpr1p; binds translation elongation factor eEF-1 (Tef1p); relative distribution to nucleus increases upon DNA replication stress; human ZPR1 gene can complement yeast by allowing growth during down-regulation of yeast zpr1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    915241..916701
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181340.3 → NP_011727.3  TPA: zinc finger-containing protein ZPR1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011727.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VUZ4, P53303, Q02807, Q02808
    UniProtKB/TrEMBL
    A6ZUM2, B3LI25, B5VJF1, C7GRP4, C8Z9A4, G2WEU0, N1P2J7
    Conserved Domains (2) summary
    TIGR00310
    Location:293 → 486
    ZPR1_znf; ZPR1 zinc finger domain
    pfam03367
    Location:52 → 210
    zf-ZPR1; ZPR1 zinc-finger domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53303.1

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