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ELP2 Elongator subunit ELP2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853114, updated on 3-Nov-2024

Summary

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Official Symbol
ELP2
Official Full Name
Elongator subunit ELP2
Primary source
SGD:S000003432
Locus tag
YGR200C
See related
AllianceGenome:SGD:S000003432; FungiDB:YGR200C; VEuPathDB:YGR200C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
KTI3; TOT2
Summary
Enables microtubule binding activity. Involved in protein urmylation; regulation of transcription by RNA polymerase II; and tRNA wobble uridine modification. Located in cytoplasm and nucleus. Part of elongator holoenzyme complex. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 58. Orthologous to human ELP2 (elongator acetyltransferase complex subunit 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ELP2 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (899904..902270, complement)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Ypp1p Neighboring gene dolichyl-phosphate-mannose-protein mannosyltransferase PMT6 Neighboring gene uncharacterized protein Neighboring gene choline-phosphate cytidylyltransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Use of a Yeast tRNase Killer Toxin to Diagnose Kti12 Motifs Required for tRNA Modification by Elongator. Mehlgarten C, et al. Toxins (Basel), 2017 Sep 5. PMID 28872616, Free PMC Article
  2. Molecular basis of tRNA recognition by the Elongator complex. Dauden MI, et al. Sci Adv, 2019 Jul. PMID 31309145, Free PMC Article
  3. Intracellular expression of Kluyveromyces lactis toxin gamma subunit mimics treatment with exogenous toxin and distinguishes two classes of toxin-resistant mutant. Butler AR, et al. Yeast, 1991 Aug-Sep. PMID 1767590
  4. The tRNA modification complex elongator regulates the Cdc42-dependent mitogen-activated protein kinase pathway that controls filamentous growth in yeast. Abdullah U, et al. Eukaryot Cell, 2009 Sep. PMID 19633267, Free PMC Article
  5. Elp1p, the yeast homolog of the FD disease syndrome protein, negatively regulates exocytosis independently of transcriptional elongation. Rahl PB, et al. Mol Cell, 2005 Mar 18. PMID 15780940

See all (123) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables microtubule binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein urmylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA wobble uridine modification IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA wobble uridine modification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of elongator holoenzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of elongator holoenzyme complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of elongator holoenzyme complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Elongator subunit ELP2
NP_011716.3
  • Subunit of Elongator complex; binds to microtubules via conserved alkaline residues; has two seven-bladed WD40 beta propellers; Elongator complex is required for modification of wobble nucleosides in tRNA; target of Kluyveromyces lactis zymocin

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    899904..902270 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181329.3 → NP_011716.3  TPA: Elongator subunit ELP2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011716.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VUY2, E9P8V1, P42935
    UniProtKB/TrEMBL
    B5VJE3, N1P629
    Conserved Domains (3) summary
    cd00200
    Location:52 → 413
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:62 → 102
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:554 → 786
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P42935.1

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