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OKP1 Okp1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853090, updated on 2-Nov-2024

Summary

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Official Symbol
OKP1
Official Full Name
Okp1p
Primary source
SGD:S000003411
Locus tag
YGR179C
See related
AllianceGenome:SGD:S000003411; FungiDB:YGR179C; VEuPathDB:YGR179C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in attachment of spindle microtubules to kinetochore. Located in kinetochore. Part of COMA complex. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See OKP1 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (853675..854895, complement)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene alcohol O-acetyltransferase Neighboring gene Pbp1p Neighboring gene ribonucleotide-diphosphate reductase subunit RNR4 Neighboring gene tRNA-Leu

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Spindle checkpoint maintenance requires Ame1 and Okp1. Pot I, et al. Cell Cycle, 2005 Oct. PMID 16177574
  2. Changes in the localization of the Saccharomyces cerevisiae anaphase-promoting complex upon microtubule depolymerization and spindle checkpoint activation. Melloy PG, et al. Genetics, 2004 Jul. PMID 15280225, Free PMC Article
  3. Phosphorylation of centromeric histone H3 variant regulates chromosome segregation in Saccharomyces cerevisiae. Boeckmann L, et al. Mol Biol Cell, 2013 Jun. PMID 23637466, Free PMC Article
  4. Kinetochores generate microtubules with distal plus ends: their roles and limited lifetime in mitosis. Kitamura E, et al. Dev Cell, 2010 Feb 16. PMID 20159595, Free PMC Article
  5. The COMA complex is required for Sli15/INCENP-mediated correction of defective kinetochore attachments. Knockleby J, et al. Cell Cycle, 2009 Aug 15. PMID 19597337

See all (78) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Recognition of centromere-specific histone Cse4 by the inner kinetochore Okp1-Ame1 complex.
    Title: Recognition of centromere-specific histone Cse4 by the inner kinetochore Okp1-Ame1 complex.
  2. Overexpression of OKP1 restores kinetochore localization of the mutant Ame1-4 protein, Sli15 localization is not restored and defective attachments are not corrected.
    Title: The COMA complex is required for Sli15/INCENP-mediated correction of defective kinetochore attachments.
  3. Ame1 and Okp1 are required for a sustained checkpoint arrest in the presence of mis-segregated chromosomes
    Title: Spindle checkpoint maintenance requires Ame1 and Okp1.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in attachment of spindle microtubules to kinetochore IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of COMA complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
  
located_in kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 
located_in kinetochore IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Okp1p
NP_011695.1
  • Outer kinetochore protein required for accurate chromosome segregation; component of COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) a kinetochore sub-complex which functions as a platform for kinetochore assembly; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-Q and fission yeast fta7

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    853675..854895 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181308.1 → NP_011695.1  TPA: Okp1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011695.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VUW3, P53298
    UniProtKB/TrEMBL
    G2WEQ9, N1P612
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53298.1

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