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CHO2 phosphatidylethanolamine N-methyltransferase [ Saccharomyces cerevisiae S288C ]

Gene ID: 853061, updated on 2-Nov-2024

Summary

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Official Symbol
CHO2
Official Full Name
phosphatidylethanolamine N-methyltransferase
Primary source
SGD:S000003389
Locus tag
YGR157W
See related
AllianceGenome:SGD:S000003389; FungiDB:YGR157W; VEuPathDB:YGR157W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
PEM1
Summary
Enables phosphatidylethanolamine N-methyltransferase activity. Involved in phosphatidylcholine biosynthetic process. Located in cell periphery and endoplasmic reticulum. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See CHO2 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (802440..805049)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene cystathionine beta-synthase CYS4 Neighboring gene cleavage polyadenylation factor subunit PTI1 Neighboring gene exosome non-catalytic core subunit MTR3 Neighboring gene Nsr1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Expression of the Saccharomyces cerevisiae inositol-1-phosphate synthase (INO1) gene is regulated by factors that affect phospholipid synthesis. Hirsch JP, et al. Mol Cell Biol, 1986 Oct. PMID 3025587, Free PMC Article
  2. Saccharomyces cerevisiae cho2 mutants are deficient in phospholipid methylation and cross-pathway regulation of inositol synthesis. Summers EF, et al. Genetics, 1988 Dec. PMID 3066687, Free PMC Article
  3. Regulation of phosphatidylethanolamine methyltransferase level by myo-inositol in Saccaromyces cerevisiae. Yamashita S, et al. Eur J Biochem, 1980 Mar. PMID 6988218
  4. Identification of the upstream activation sequences responsible for the expression and regulation of the PEM1 and PEM2 genes encoding the enzymes of the phosphatidylethanolamine methylation pathway in Saccharomyces cerevisiae. Kodaki T, et al. J Biochem, 1991 Feb. PMID 1650774
  5. Quantitative profiling of PE, MMPE, DMPE, and PC lipid species by multiple precursor ion scanning: a tool for monitoring PE metabolism. Bilgin M, et al. Biochim Biophys Acta, 2011 Dec. PMID 22001639

See all (135) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylethanolamine N-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylethanolamine N-methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylethanolamine N-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylethanolamine N-methyltransferase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables phosphatidylethanolamine N-methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylcholine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylcholine biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phosphatidylcholine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylcholine biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in phosphatidylcholine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phospholipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell periphery HDA PubMed 
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
phosphatidylethanolamine N-methyltransferase
NP_011673.1
  • Phosphatidylethanolamine methyltransferase (PEMT); catalyzes the first step in the conversion of phosphatidylethanolamine to phosphatidylcholine during the methylation pathway of phosphatidylcholine biosynthesis

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    802440..805049
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181286.1 → NP_011673.1  TPA: phosphatidylethanolamine N-methyltransferase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011673.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B5VJA0, D6VUT7, P05374
    UniProtKB/TrEMBL
    G2WEN7, N1P2E1
    Conserved Domains (1) summary
    pfam04191
    Location:471 → 577
    PEMT; Phospholipid methyltransferase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P05374.1

Gene LinkOut

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