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PCP1 rhomboid protease PCP1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852993, updated on 2-Nov-2024

Summary

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Official Symbol
PCP1
Official Full Name
rhomboid protease PCP1
Primary source
SGD:S000003333
Locus tag
YGR101W
See related
AllianceGenome:SGD:S000003333; FungiDB:YGR101W; VEuPathDB:YGR101W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
MDM37; RBD1; UGO2
Summary
Enables serine-type endopeptidase activity. Involved in regulation of mitochondrion organization and signal peptide processing. Located in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in Leber hereditary optic neuropathy; coronary artery disease; hyperinsulinism; myopia; and type 2 diabetes mellitus. Orthologous to human PARL (presenilin associated rhomboid like). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See PCP1 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (693363..694403)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Tel2p Neighboring gene GTPase-activating protein MDR1 Neighboring gene glutamyl-tRNA(Gln) amidotransferase subunit F Neighboring gene mRNA-binding ribosome synthesis protein NOP7

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mitochondrial signal peptidases of yeast: the rhomboid peptidase Pcp1 and its substrate cytochrome C peroxidase. Michaelis G, et al. Gene, 2005 Jul 18. PMID 15979251
  2. Single amino acid mutations in the Saccharomyces cerevisiae rhomboid peptidase, Pcp1p, alter mitochondrial morphology. Huddleston ME, et al. Cell Biol Int, 2020 Jan. PMID 31441130, Free PMC Article
  3. Processing of Mgm1 by the rhomboid-type protease Pcp1 is required for maintenance of mitochondrial morphology and of mitochondrial DNA. Herlan M, et al. J Biol Chem, 2003 Jul 25. PMID 12707284
  4. Alternative topogenesis of Mgm1 and mitochondrial morphology depend on ATP and a functional import motor. Herlan M, et al. J Cell Biol, 2004 Apr 26. PMID 15096522, Free PMC Article
  5. Intramembrane proteolysis of Mgm1 by the mitochondrial rhomboid protease is highly promiscuous regarding the sequence of the cleaved hydrophobic segment. Schäfer A, et al. J Mol Biol, 2010 Aug 13. PMID 20558178

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. transmembrane segments of inner membrane proteins that are normally not processed by Pcp1 become cleavable when put in place of the authentic 'rhomboid cleavage region' (RCR) of Mgm1
    Title: Intramembrane proteolysis of Mgm1 by the mitochondrial rhomboid protease is highly promiscuous regarding the sequence of the cleaved hydrophobic segment.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal peptide processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal peptide processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
rhomboid protease PCP1
NP_011615.1
  • Mitochondrial serine protease; required for the processing of various mitochondrial proteins and maintenance of mitochondrial DNA and morphology; belongs to the rhomboid-GlpG superfamily of intramembrane peptidases

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    693363..694403
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181230.1 → NP_011615.1  TPA: rhomboid protease PCP1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011615.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VUN3, P53259
    UniProtKB/TrEMBL
    A6ZV83, B3LIC5, C7GWW2, C8Z8Z4, N1P401
    Conserved Domains (1) summary
    pfam01694
    Location:186 → 329
    Rhomboid; Rhomboid family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53259.1

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