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VHT1 Vht1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852956, updated on 2-Nov-2024

Summary

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Official Symbol
VHT1
Official Full Name
Vht1p
Primary source
SGD:S000003297
Locus tag
YGR065C
See related
AllianceGenome:SGD:S000003297; FungiDB:YGR065C; VEuPathDB:YGR065C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables biotin transmembrane transporter activity. Involved in biotin transport. Located in plasma membrane. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 25; gout; porokeratosis; and sialuria. Orthologous to several human genes including SLC17A1 (solute carrier family 17 member 1); SLC17A2 (solute carrier family 17 member 2); and SLC17A3 (solute carrier family 17 member 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See VHT1 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (618077..619858, complement)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene membrane insertase COX18 Neighboring gene transcription elongation factor SPT4 Neighboring gene Gid10p Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of the plasma membrane H+-biotin symporter of Saccharomyces cerevisiae by rescue of a fatty acid-auxotrophic mutant. Stolz J, et al. J Biol Chem, 1999 Jun 25. PMID 10373489
  2. Isolation and characterization of the plasma membrane biotin transporter from Schizosaccharomyces pombe. Stolz J. Yeast, 2003 Feb. PMID 12557275
  3. Vhr1p, a new transcription factor from budding yeast, regulates biotin-dependent expression of VHT1 and BIO5. Weider M, et al. J Biol Chem, 2006 May 12. PMID 16533810
  4. Cell division defects of Schizosaccharomyces pombe liz1- mutants are caused by defects in pantothenate uptake. Stolz J, et al. Eukaryot Cell, 2004 Apr. PMID 15075270, Free PMC Article
  5. Biotin sensing in Saccharomyces cerevisiae is mediated by a conserved DNA element and requires the activity of biotin-protein ligase. Pirner HM, et al. J Biol Chem, 2006 May 5. PMID 16531611

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. a conserved DNA element mediates biotin sensing in Saccharomyces cerevisiae with biotin-protein ligase Vht1p
    Title: Biotin sensing in Saccharomyces cerevisiae is mediated by a conserved DNA element and requires the activity of biotin-protein ligase.
  2. The presented data characterize Vhr1p as an essential component of the biotin-dependent signal transduction cascade in yeast.
    Title: Vhr1p, a new transcription factor from budding yeast, regulates biotin-dependent expression of VHT1 and BIO5.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables biotin transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables symporter activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biotin transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell periphery HDA PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Vht1p
NP_011579.1
  • High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    618077..619858 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181194.1 → NP_011579.1  TPA: Vht1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011579.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VUJ9, P53241
    UniProtKB/TrEMBL
    A6ZV49, B3LIF9, C7GXP7, N1P3I8
    Conserved Domains (1) summary
    cd17327
    Location:124 → 542
    MFS_FEN2_like; Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53241.1

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