ERG25 methylsterol monooxygenase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: ERG25
Official Full Name: methylsterol monooxygenase
Primary source: SGD:S000003292
Locus tag: YGR060W
See related: AllianceGenome:SGD:S000003292; FungiDB:YGR060W; VEuPathDB:YGR060W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables C-4 methylsterol oxidase activity. Involved in ergosterol biosynthetic process. Located in endoplasmic reticulum membrane and plasma membrane. Is active in endoplasmic reticulum. Orthologous to human MSMO1 (methylsterol monooxygenase 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ERG25 in Genome Data Viewer

Location:: chromosome: VII

Exon count:: 1

Sequence:: Chromosome: VII; NC_001139.9 (610564..611493)

Chromosome VII - NC_001139.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Capture of a Disabled Proteasome Identifies Erg25 as a Substrate for Endoplasmic Reticulum Associated Degradation.
Title: The Capture of a Disabled Proteasome Identifies Erg25 as a Substrate for Endoplasmic Reticulum Associated Degradation.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables C-4 methylsterol oxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables C-4 methylsterol oxidase activity	IDA Inferred from Direct Assay more info	PubMed
enables C-4 methylsterol oxidase activity	IEA Inferred from Electronic Annotation more info
enables C-4 methylsterol oxidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ergosterol biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ergosterol biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in ergosterol biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in sterol biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum	IPI Inferred from Physical Interaction more info	PubMed
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: methylsterol monooxygenase

NP_011574.3

C-4 methyl sterol oxidase; catalyzes the first of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants accumulate the sterol intermediate 4,4-dimethylzymosterol; human MSMO1 functionally complements the growth defect caused by repression of ERG25 expression

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001139.9 Reference assembly

Range

610564..611493

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181189.3 → NP_011574.3 TPA: methylsterol monooxygenase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_011574.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VUJ5, E9P8T3, P53045, Q45U26

UniProtKB/TrEMBL

A6ZV45, B3LIG3, B5VJ10, C7GXP3, C8Z8V4, G2WEE7, N1P254

Conserved Domains (1) summary

COG3000
Location:35 → 307

ERG3; Sterol desaturase/sphingolipid hydroxylase, fatty acid hydroxylase superfamily [Lipid transport and metabolism]