ORM1 sphingolipid homeostasis protein ORM1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: ORM1
Official Full Name: sphingolipid homeostasis protein ORM1
Primary source: SGD:S000003270
Locus tag: YGR038W
See related: AllianceGenome:SGD:S000003270; FungiDB:YGR038W; VEuPathDB:YGR038W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Involved in negative regulation of sphingolipid biosynthetic process and response to unfolded protein. Located in endoplasmic reticulum. Part of serine palmitoyltransferase complex. Orthologous to human ORMDL1 (ORMDL sphingolipid biosynthesis regulator 1); ORMDL2 (ORMDL sphingolipid biosynthesis regulator 2); and ORMDL3 (ORMDL sphingolipid biosynthesis regulator 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ORM1 in Genome Data Viewer

Location:: chromosome: VII

Exon count:: 1

Sequence:: Chromosome: VII; NC_001139.9 (560682..561350)

Chromosome VII - NC_001139.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Regulation of sphingolipid biosynthesis in the endoplasmic reticulum via signals from the plasma membrane in budding yeast.
Title: Regulation of sphingolipid biosynthesis in the endoplasmic reticulum via signals from the plasma membrane in budding yeast.
Data indicate that Orm1 and Orm2 proteins respond to feedback signals from the sphingolipid synthesis pathway.
Title: Orm proteins integrate multiple signals to maintain sphingolipid homeostasis.
Npr1-phosphorylated Orm1 and Orm2 stimulate de novo synthesis of complex sphingolipids downstream of serine palmitoyltransferase.
Title: TORC1-regulated protein kinase Npr1 phosphorylates Orm to stimulate complex sphingolipid synthesis.
Orm1 and Orm2 regulated the synthesis of sphingolipid.
Title: Regulation of sphingolipid synthesis through Orm1 and Orm2 in yeast.
Data show a mechanism through which the conserved Pkh-Ypk kinase cascade and Cdc55-PP2A facilitate rapid, transient sphingolipid production in response to heat stress through Orm protein phosphoregulation.
Title: Orm protein phosphoregulation mediates transient sphingolipid biosynthesis response to heat stress via the Pkh-Ypk and Cdc55-PP2A pathways.
Physical interaction between Orm1 and Orm2 and serine palmitoyltransferase, responsible for the first committed step in sphingolipid synthesis, further supports a role for the Orm proteins in regulating sphingolipid synthesis.
Title: Orm1 and Orm2 are conserved endoplasmic reticulum membrane proteins regulating lipid homeostasis and protein quality control.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in ceramide metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular sphingolipid homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of sphingolipid biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of sphingolipid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of sphingolipid biosynthetic process	IPI Inferred from Physical Interaction more info	PubMed
involved_in response to unfolded protein	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sphingolipid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	HDA more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of serine palmitoyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of serine palmitoyltransferase complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: sphingolipid homeostasis protein ORM1

NP_011552.1

Protein that mediates sphingolipid homeostasis; evolutionarily conserved, required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control; ORM1 has a paralog, ORM2, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001139.9 Reference assembly

Range

560682..561350

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181167.1 → NP_011552.1 TPA: sphingolipid homeostasis protein ORM1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_011552.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VUH5, P53224

UniProtKB/TrEMBL

A6ZV27, B3LII2, C7GKA5, C8Z8T4, E9P997, G2WEC9, N1P235

Conserved Domains (1) summary

COG5081
Location:42 → 222

COG5081; Predicted membrane protein [Function unknown]