GSC2 1,3-beta-glucan synthase GSC2 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: GSC2
Official Full Name: 1,3-beta-glucan synthase GSC2
Primary source: SGD:S000003264
Locus tag: YGR032W
See related: AllianceGenome:SGD:S000003264; FungiDB:YGR032W; VEuPathDB:YGR032W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: FKS2
Summary: Enables 1,3-beta-D-glucan synthase activity. Involved in (1->3)-beta-D-glucan biosynthetic process and ascospore wall assembly. Located in prospore membrane. Part of 1,3-beta-D-glucan synthase complex. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See GSC2 in Genome Data Viewer

Location:: chromosome: VII

Exon count:: 1

Sequence:: Chromosome: VII; NC_001139.9 (548264..553951)

Chromosome VII - NC_001139.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ste11 regulates the FKS2 gene through its substrates and through Mpk1.
Title: Ste11p MEKK signals through HOG, mating, calcineurin and PKC pathways to regulate the FKS2 gene.
The dimeric complex of Mpk1 binds to a Swi4 recognition site in the FKS2 promoter.[Mpk1, Swi4, FKS2]
Title: Transcriptional reporters for genes activated by cell wall stress through a non-catalytic mechanism involving Mpk1 and SBF.
negative regulation of GSC2 by SMK1 is important for spore wall deposition
Title: The Smk1p MAP kinase negatively regulates Gsc2p, a 1,3-beta-glucan synthase, during spore wall morphogenesis in Saccharomyces cerevisiae.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables 1,3-beta-D-glucan synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 1,3-beta-D-glucan synthase activity	IDA Inferred from Direct Assay more info	PubMed
enables 1,3-beta-D-glucan synthase activity	IEA Inferred from Electronic Annotation more info
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in (1->3)-beta-D-glucan biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in (1->3)-beta-D-glucan biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in (1->3)-beta-D-glucan biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in (1->3)-beta-D-glucan biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ascospore wall assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in ascospore wall assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell wall organization	IEA Inferred from Electronic Annotation more info
involved_in fungal-type cell wall polysaccharide biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in sporulation resulting in formation of a cellular spore	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of 1,3-beta-D-glucan synthase complex	IDA Inferred from Direct Assay more info	PubMed
part_of 1,3-beta-D-glucan synthase complex	IEA Inferred from Electronic Annotation more info
located_in cell periphery	HDA more info	PubMed
located_in cellular bud neck	HDA more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in prospore membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: 1,3-beta-glucan synthase GSC2

NP_011546.3

EC 2.4.1.34

Catalytic subunit of 1,3-beta-glucan synthase; involved in formation of the inner layer of the spore wall; activity positively regulated by Rho1p and negatively by Smk1p; GSC2 has a paralog, FKS1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001139.9 Reference assembly

Range

548264..553951

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181161.3 → NP_011546.3 TPA: 1,3-beta-glucan synthase GSC2 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_011546.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VUG8, P40989, Q45U52

UniProtKB/TrEMBL

G2WEC2, N1P5P7

Conserved Domains (2) summary

pfam02364
Location:827 → 1650

Glucan_synthase; 1,3-beta-glucan synthase component

pfam14288
Location:320 → 428

FKS1_dom1; 1,3-beta-glucan synthase subunit FKS1, domain-1