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MTL1 Mtl1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852905, updated on 2-Nov-2024

Summary

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Official Symbol
MTL1
Official Full Name
Mtl1p
Primary source
SGD:S000003255
Locus tag
YGR023W
See related
AllianceGenome:SGD:S000003255; FungiDB:YGR023W; VEuPathDB:YGR023W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in cellular response to glucose starvation; cellular response to oxidative stress; and fungal-type cell wall organization. Located in plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See MTL1 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (529264..530919)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene H(+)-transporting V1 sector ATPase subunit F Neighboring gene Dpc29p Neighboring gene tRNA-Asp Neighboring gene tRNA guanylyltransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Cell Wall Integrity Receptor Mtl1 Contributes to Articulate Autophagic Responses When Glucose Availability Is Compromised. Montella-Manuel S, et al. J Fungi (Basel), 2021 Oct 26. PMID 34829194, Free PMC Article
  2. Toward the discovery of biological functions associated with the mechanosensor Mtl1p of Saccharomyces cerevisiae via integrative multi-OMICs analysis. Martínez-Matías N, et al. Sci Rep, 2021 Apr 1. PMID 33795741, Free PMC Article
  3. Signal flow between CWI/TOR and CWI/RAS in budding yeast under conditions of oxidative stress and glucose starvation. Petkova MI, et al. Commun Integr Biol, 2010 Nov. PMID 21331237, Free PMC Article
  4. Stability control of MTL1 mRNA by the RNA-binding protein Khd1p in yeast. Mauchi N, et al. Cell Struct Funct, 2010. PMID 20953064
  5. Mid2 is a putative sensor for cell integrity signaling in Saccharomyces cerevisiae. Rajavel M, et al. Mol Cell Biol, 1999 Jun. PMID 10330137, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mtl1, member of the cell wall integrity pathway of Saccharomyces cerevisiae, plays a positive role in chronological life span (CLS).
    Title: Tor1, Sch9 and PKA downregulation in quiescence rely on Mtl1 to preserve mitochondrial integrity and cell survival.
  2. Mtl1 O-mannosylation mediated by both Pmt1 and Pmt2 is important for cell survival under oxidative conditions and TOR blockade.
    Title: Mtl1 O-mannosylation mediated by both Pmt1 and Pmt2 is important for cell survival under oxidative conditions and TOR blockade.
  3. results suggest that MTL1 mRNA bears a cis-acting element involved in destabilization by the decapping enzyme and the 5'-3' exonuclease, and Khd1p stabilizes MTL1 mRNA through binding to this element
    Title: Stability control of MTL1 mRNA by the RNA-binding protein Khd1p in yeast.
  4. Mtl1 has an essential role in signaling oxidative stress and quiescence to the CWI pathway and to the general stress response through Rho1 and the inhibition of either the TOR1 or RAS2 functions
    Title: Mtl1 is required to activate general stress response through Tor1 and Ras2 inhibition under conditions of glucose starvation and oxidative stress.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in cellular response to glucose starvation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to glucose starvation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cellular response to glucose starvation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to oxidative stress IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cellular response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in fungal-type cell wall organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein catabolic process in the vacuole IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in vacuole IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Mtl1p
NP_011537.1
  • Transmembrane sensor of the cell wall integrity pathway (CWI); involved in cell integrity signaling and stress response during glucose starvation and oxidative stress; structurally and functionally similar to Mid2p; MTL1 has a paralog, MID2, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    529264..530919
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181152.1 → NP_011537.1  TPA: Mtl1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011537.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VUF7, P53214, Q45U60
    UniProtKB/TrEMBL
    A6ZV12
    Conserved Domains (1) summary
    pfam04478
    Location:315 → 466
    Mid2; Mid2 like cell wall stress sensor
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53214.1

Gene LinkOut

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