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SWC4 Swc4p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852885, updated on 2-Nov-2024

Summary

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Official Symbol
SWC4
Official Full Name
Swc4p
Primary source
SGD:S000003234
Locus tag
YGR002C
See related
AllianceGenome:SGD:S000003234; FungiDB:YGR002C; VEuPathDB:YGR002C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
EAF2; GOD1
Summary
Predicted to enable transcription corepressor activity. Involved in DNA repair; chromatin remodeling; and chromosome organization. Located in nucleus. Part of NuA4 histone acetyltransferase complex and Swr1 complex. Orthologous to human DMAP1 (DNA methyltransferase 1 associated protein 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See SWC4 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (498476..499906, complement)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) Neighboring gene protein-lysine N-methyltransferase Neighboring gene cullin CUL3 Neighboring gene peroxisome biogenesis protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Direct physical and functional interaction of the NuA4 complex components Yaf9p and Swc4p. Bittner CB, et al. Eukaryot Cell, 2004 Aug. PMID 15302830, Free PMC Article
  2. The yeast NuA4 and Drosophila MSL complexes contain homologous subunits important for transcription regulation. Eisen A, et al. J Biol Chem, 2001 Feb 2. PMID 11036083
  3. The essential function of Swc4p - a protein shared by two chromatin-modifying complexes of the yeast Saccharomyces cerevisiae - resides within its N-terminal part. Miciałkiewicz A, et al. Acta Biochim Pol, 2008. PMID 18726008
  4. Yeast enhancer of polycomb defines global Esa1-dependent acetylation of chromatin. Boudreault AA, et al. Genes Dev, 2003 Jun 1. PMID 12782659, Free PMC Article
  5. Swc4 protects nucleosome-free rDNA, tDNA and telomere loci to inhibit genome instability. Pan Y, et al. DNA Repair (Amst), 2023 Jul. PMID 37230009

See all (88) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Swc4 protects nucleosome-free rDNA, tDNA and telomere loci to inhibit genome instability.
    Title: Swc4 protects nucleosome-free rDNA, tDNA and telomere loci to inhibit genome instability.
  2. Swc4 positively regulates telomere length independently of its roles in NuA4 and SWR1 complexes.
    Title: Swc4 positively regulates telomere length independently of its roles in NuA4 and SWR1 complexes.
  3. N-terminal region of the Swr1 ATPase subunit is necessary and sufficient to direct association of Bdf1 and Swc7, as well as Arp4, Act1, Yaf9 and Swc4. This same region contains an additional H2AZ-H2B specific binding site.
    Title: N terminus of Swr1 binds to histone H2AZ and provides a platform for subunit assembly in the chromatin remodeling complex.
  4. Using random mutagenesis we isolated a collection of swc4 mutants and showed that the essential function of Swc4p resides in its N-terminal part, within the first 269 amino acids of the 476-amino acid-long protein.
    Title: The essential function of Swc4p - a protein shared by two chromatin-modifying complexes of the yeast Saccharomyces cerevisiae - resides within its N-terminal part.
  5. Results suggest that Yaf9p and Swc4p form a protein pair that has a role in chromatin modification with possible implications also for the function of their mammalian counterparts.
    Title: Direct physical and functional interaction of the NuA4 complex components Yaf9p and Swc4p.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in DNA repair IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in chromosome organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of NuA4 histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of NuA4 histone acetyltransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of NuA4 histone acetyltransferase complex IEA
Inferred from Electronic Annotation
more info
  
part_of Swr1 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Swr1 complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Swc4p
NP_011516.1
  • Component of the Swr1p complex that incorporates Htz1p into chromatin; component of the NuA4 histone acetyltransferase complex; associates with and protects nucleosome-free regions of the genome including rDNA, tDNA and telomeric loci, contributing to genome integrity

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    498476..499906 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181131.1 → NP_011516.1  TPA: Swc4p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011516.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VUD9, P53201
    UniProtKB/TrEMBL
    G2WE95, N1P9T6
    Conserved Domains (1) summary
    pfam16282
    Location:109 → 213
    SANT_DAMP1_like; SANT/Myb-like domain of DAMP1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53201.1

Gene LinkOut

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