ERG26 sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: ERG26
Official Full Name: sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating)
Primary source: SGD:S000002969
Locus tag: YGL001C
See related: AllianceGenome:SGD:S000002969; FungiDB:YGL001C; VEuPathDB:YGL001C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity and sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity. Involved in ergosterol biosynthetic process. Located in endoplasmic reticulum membrane. Used to study cancer. Human ortholog(s) of this gene implicated in CHILD syndrome and CK syndrome. Orthologous to human NSDHL (NAD(P) dependent steroid dehydrogenase-like). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ERG26 in Genome Data Viewer

Location:: chromosome: VII

Exon count:: 1

Sequence:: Chromosome: VII; NC_001139.9 (495453..496502, complement)

Chromosome VII - NC_001139.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating) [NAD(+)] activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity	IBA Inferred from Biological aspect of Ancestor more info
enables C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity	IDA Inferred from Direct Assay more info	PubMed
enables C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ergosterol biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ergosterol biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in ergosterol biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in steroid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in sterol biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	HDA more info	PubMed
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating)

NP_011514.1

EC 1.1.1.170

C-3 sterol dehydrogenase; catalyzes the second of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; human homolog NSDHL implicated in CK syndrome, and can complement yeast null mutant; molecular target of natural product and antifungal compound FR171456

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001139.9 Reference assembly

Range

495453..496502 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180866.1 → NP_011514.1 TPA: sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_011514.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VUD7, P53199

UniProtKB/TrEMBL

A6ZUZ2, B3LIL6, B5VIW1, C7GK71, C8Z8P4, G2WE93, N1P3D7

Conserved Domains (1) summary

cd09813
Location:6 → 345

3b-HSD-NSDHL-like_SDR_e; human NSDHL (NAD(P)H steroid dehydrogenase-like protein)-like, extended (e) SDRs