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SCL1 proteasome core particle subunit alpha 1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852873, updated on 2-Nov-2024

Summary

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Official Symbol
SCL1
Official Full Name
proteasome core particle subunit alpha 1
Primary source
SGD:S000002979
Locus tag
YGL011C
See related
AllianceGenome:SGD:S000002979; FungiDB:YGL011C; VEuPathDB:YGL011C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
PRC2
Summary
Involved in proteasomal ubiquitin-independent protein catabolic process and proteasome-mediated ubiquitin-dependent protein catabolic process. Located in mitochondrion. Part of proteasome core complex, alpha-subunit complex. Human ortholog(s) of this gene implicated in myocardial infarction. Orthologous to human PSMA6 (proteasome 20S subunit alpha 6). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See SCL1 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (474489..475247, complement)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene drug-responsive transcription factor PDR1 Neighboring gene delta(24(24(1)))-sterol reductase Neighboring gene Mpo1p Neighboring gene 3-isopropylmalate dehydratase LEU1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of a Saccharomyces cerevisiae mutant with pseudohyphae and cloning of a gene complementing the mutation. Maneesri J, et al. Biosci Biotechnol Biochem, 2003 Mar. PMID 12723598
  2. Proteasomes are essential for yeast proliferation. cDNA cloning and gene disruption of two major subunits. Fujiwara T, et al. J Biol Chem, 1990 Sep 25. PMID 1697860
  3. Molecular cloning of the yeast proteasome PRS2 gene identical to the suppressor gene scl1+. Lee DH, et al. Biochem Int, 1991 Mar. PMID 1872882
  4. The suppressor gene scl1+ of Saccharomyces cerevisiae is essential for growth. Balzi E, et al. Gene, 1989 Nov 30. PMID 2684789
  5. Molecular cloning and functional analysis of three subunits of yeast proteasome. Emori Y, et al. Mol Cell Biol, 1991 Jan. PMID 1898763, Free PMC Article

See all (102) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in proteasomal ubiquitin-independent protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proteasomal ubiquitin-independent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of proteasome complex IEA
Inferred from Electronic Annotation
more info
  
part_of proteasome core complex IEA
Inferred from Electronic Annotation
more info
  
part_of proteasome core complex, alpha-subunit complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of proteasome core complex, alpha-subunit complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of proteasome core complex, alpha-subunit complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
proteasome core particle subunit alpha 1
NP_011504.3
  • Alpha 1 subunit of the 20S proteasome; involved in the degradation of ubiquitinated substrates; 20S proteasome is the core complex of the 26S proteasome; essential for growth; detected in the mitochondria

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    474489..475247 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180876.3 → NP_011504.3  TPA: proteasome core particle subunit alpha 1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011504.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VUC6, P15708, P21243
    UniProtKB/TrEMBL
    A6ZUY2, B3LIM6, B5VIV2, C7GK62, C8Z8N2, G2WE82, N1P3C8
    Conserved Domains (1) summary
    cd03754
    Location:12 → 228
    proteasome_alpha_type_6; The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on top of one another forming ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P21243.1

Gene LinkOut

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