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PGD1 Pgd1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852860, updated on 2-Nov-2024

Summary

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Official Symbol
PGD1
Official Full Name
Pgd1p
Primary source
SGD:S000002993
Locus tag
YGL025C
See related
AllianceGenome:SGD:S000002993; FungiDB:YGL025C; VEuPathDB:YGL025C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
HRS1; MED3
Summary
Enables RNA polymerase II core promoter sequence-specific DNA binding activity; RNA polymerase II-specific DNA-binding transcription factor binding activity; and transcription coactivator activity. Involved in RNA polymerase II preinitiation complex assembly; cellular response to heat; and regulation of transcription by RNA polymerase II. Part of core mediator complex. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See PGD1 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (448764..449957, complement)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene mannosyl-oligosaccharide glucosidase Neighboring gene tryptophan synthase TRP5 Neighboring gene Pib2p Neighboring gene dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The yeast HRS1 gene encodes a polyglutamine-rich nuclear protein required for spontaneous and hpr1-induced deletions between direct repeats. Santos-Rosa H, et al. Genetics, 1996 Mar. PMID 8849881, Free PMC Article
  2. Med3-mediated NADPH generation to help Saccharomyces cerevisiae tolerate hyperosmotic stress. Hou S, et al. Appl Environ Microbiol, 2024 Aug 21. PMID 39082808,
  3. Proteolytic instability and the action of nonclassical transcriptional activators. Wang X, et al. Curr Biol, 2010 May 11. PMID 20417106, Free PMC Article
  4. Isolation and genetic analysis of extragenic suppressors of the hyper-deletion phenotype of the Saccharomyces cerevisiae hpr1 delta mutation. Santos-Rosa H, et al. Genetics, 1995 Jan. PMID 7705651, Free PMC Article
  5. Suppression of Mediator is regulated by Cdk8-dependent Grr1 turnover of the Med3 coactivator. Gonzalez D, et al. Proc Natl Acad Sci U S A, 2014 Feb 18. PMID 24550274, Free PMC Article

See all (117) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The function of the Mediator tail module component Med3, which is required for transcription activation, is suppressed by the kinase activity of the Cdk8 module.
    Title: Suppression of Mediator is regulated by Cdk8-dependent Grr1 turnover of the Med3 coactivator.
  2. Data suggest that Nhp6p and Med3p regulate gene expression by controlling the local subunit composition of RNA polymerase II.
    Title: Nhp6p and Med3p regulate gene expression by controlling the local subunit composition of RNA polymerase II.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA polymerase II core promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II-specific DNA-binding transcription factor binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coactivator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables transcription coregulator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA polymerase II preinitiation complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to heat IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of core mediator complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of mediator complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Pgd1p
NP_011490.2
  • Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for basal and activated transcription; direct target of Cyc8p-Tup1p transcriptional corepressor

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    448764..449957 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180890.1 → NP_011490.2  TPA: Pgd1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011490.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VUB3, P40356, Q6B1W3
    UniProtKB/TrEMBL
    G2WE69
    Conserved Domains (1) summary
    pfam11593
    Location:3 → 397
    Med3; Mediator complex subunit 3 fungal
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40356.2

Gene LinkOut

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