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RIM8 Rim8p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852837, updated on 3-Nov-2024

Summary

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Official Symbol
RIM8
Official Full Name
Rim8p
Primary source
SGD:S000003013
Locus tag
YGL045W
See related
AllianceGenome:SGD:S000003013; FungiDB:YGL045W; VEuPathDB:YGL045W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
ART9; PAL3; YGL046W
Summary
Predicted to enable protein-macromolecule adaptor activity and ubiquitin protein ligase binding activity. Involved in cellular response to amino acid stimulus and ubiquitin-dependent endocytosis. Located in cytoplasmic side of plasma membrane. Orthologous to several human genes including ARRDC1 (arrestin domain containing 1); ARRDC2 (arrestin domain containing 2); and ARRDC3 (arrestin domain containing 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See RIM8 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (414102..415730)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase catalytic subunit ALG13 Neighboring gene tRNA-Val Neighboring gene Rna15p Neighboring gene transcription elongation factor DST1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ambient pH signalling in ascomycetous yeasts involves homologues of the Aspergillus nidulans genes palF and paIH. Tréton B, et al. Mol Gen Genet, 2000 Apr. PMID 10821185
  2. Proteolytic activation of Rim1p, a positive regulator of yeast sporulation and invasive growth. Li W, et al. Genetics, 1997 Jan. PMID 9017390, Free PMC Article
  3. Evolutionary engineering and molecular characterization of a caffeine-resistant Saccharomyces cerevisiae strain. Sürmeli Y, et al. World J Microbiol Biotechnol, 2019 Nov 14. PMID 31728740
  4. A mechanism for protein monoubiquitination dependent on a trans-acting ubiquitin-binding domain. Herrador A, et al. J Biol Chem, 2013 Jun 7. PMID 23645667, Free PMC Article
  5. Microfluidic genome-wide profiling of intrinsic electrical properties in Saccharomyces cerevisiae. Vahey MD, et al. Lab Chip, 2013 Jul 21. PMID 23661198, Free PMC Article

See all (82) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CK1-mediated phosphorylation of Rim8 contributes to setting a signaling threshold required to inhibit the RIM pathway at acidic pH.
    Title: Casein kinase 1 controls the activation threshold of an α-arrestin by multisite phosphorylation of the interdomain hinge.
  2. found that in Saccharomyces cerevisiae, Rim8 binds to both the putative seven-transmembrane pH sensor Rim21 and the endosomal sorting complex required for transport-I subunit Vps23.
    Title: Recruitment of the ESCRT machinery to a putative seven-transmembrane-domain receptor is mediated by an arrestin-related protein.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables protein-macromolecule adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cellular response to amino acid stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ubiquitin-dependent endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Rim8p
NP_011470.4
  • Protein involved in proteolytic activation of Rim101p; part of response to alkaline pH; interacts with ESCRT-1 subunits Stp22p and Vps28p; essential for anaerobic growth; member of the arrestin-related trafficking adaptor family

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    414102..415730
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180910.3 → NP_011470.4  TPA: Rim8p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011470.4

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VU94, P53179, P53180, Q9URQ4
    UniProtKB/TrEMBL
    G2WE50, N1P391
    Conserved Domains (2) summary
    pfam02752
    Location:259 → 392
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    cl22903
    Location:39 → 201
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53179.2

Gene LinkOut

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