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SCY1 Scy1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852797, updated on 2-Nov-2024

Summary

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Official Symbol
SCY1
Official Full Name
Scy1p
Primary source
SGD:S000003051
Locus tag
YGL083W
See related
AllianceGenome:SGD:S000003051; FungiDB:YGL083W; VEuPathDB:YGL083W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable ATP binding activity and protein kinase activity. Predicted to be involved in protein phosphorylation. Located in mitochondrial matrix. Human ortholog(s) of this gene implicated in arthrogryposis multiplex congenita-4. Orthologous to human SCYL2 (SCY1 like pseudokinase 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See SCY1 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (353058..355472)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Lcl3p Neighboring gene O-acyltransferase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Gene dosage adaptations to mtDNA depletion and mitochondrial protein stress in budding yeast. McNamara JT, et al. G3 (Bethesda), 2024 Feb 7. PMID 38126114, Free PMC Article
  2. Tritium suicide selection identifies proteins involved in the uptake and intracellular transport of sterols in Saccharomyces cerevisiae. Sullivan DP, et al. Eukaryot Cell, 2009 Feb. PMID 19060182, Free PMC Article
  3. A haploproficient interaction of the transaldolase paralogue NQM1 with the transcription factor VHR1 affects stationary phase survival and oxidative stress resistance. Michel S, et al. BMC Genet, 2015 Feb 11. PMID 25887987, Free PMC Article
  4. Yeast Nst1 is a novel component of P-bodies and is a specific suppressor of proteasome base assembly defects. Cheng CL, et al. Mol Biol Cell, 2021 Oct 1. PMID 34347506, Free PMC Article
  5. Complex mutation profiles in mismatch repair and ribonucleotide reductase mutants reveal novel repair substrate specificity of MutS homolog (MSH) complexes. Lamb NA, et al. Genetics, 2022 Jul 30. PMID 35686905, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol HDA PubMed 
located_in mitochondrial matrix IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Scy1p
NP_011432.1
  • Putative kinase; suppressor of GTPase mutant; dosage-sensitive modulator of mitochondrial DNA (mtDNA) homeostasis; localizes to the mitochondrial matrix, and to the cytosol and clathrin-coated vesicles in HTP studies; similar to bovine rhodopsin kinase; may have a role in intracellular sterol transport

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    353058..355472
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180948.1 → NP_011432.1  TPA: Scy1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011432.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VU61, P53009
    UniProtKB/TrEMBL
    B5VIP1, N1P1V4
    Conserved Domains (1) summary
    cd14011
    Location:18 → 326
    PK_SCY1_like; Pseudokinase domain of Scy1-like proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53009.1

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