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RPL1B ribosomal 60S subunit protein L1B [ Saccharomyces cerevisiae S288C ]

Gene ID: 852742, updated on 29-Jun-2024

Summary

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Gene symbol
RPL1B
Gene description
ribosomal 60S subunit protein L1B
Primary source
FungiDB:YGL135W
Locus tag
YGL135W
See related
SGD:S000003103; AllianceGenome:SGD:S000003103; VEuPathDB:YGL135W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
SSM2
Summary
Predicted to enable RNA binding activity. Involved in ribosomal large subunit export from nucleus. Part of cytosolic large ribosomal subunit. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See RPL1B in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (254641..255294)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene coatomer subunit beta' Neighboring gene 21S rRNA (uridine2791-2'-O) methyltransferase Neighboring gene Pcl10p Neighboring gene Itc1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Eukaryotic cells producing ribosomes deficient in Rpl1 are hypersensitive to defects in the ubiquitin-proteasome system. McIntosh KB, et al. PLoS One, 2011. PMID 21858174, Free PMC Article
  2. Sequence analysis of a 14.6 kb DNA fragment of Saccharomyces cerevisiae chromosome VII reveals SEC27, SSM1b, a putative S-adenosylmethionine-dependent enzyme and six new open reading frames. Escribano V, et al. Yeast, 1996 Jul. PMID 8840506
  3. Autoregulation of yeast ribosomal proteins discovered by efficient search for feedback regulation. Roy B, et al. Commun Biol, 2020 Dec 11. PMID 33311538, Free PMC Article
  4. The accessibility of yeast ribosomal protein L1 as probed by proteolysis and site-directed mutagenesis is different in intact 60 and 80 S ribosome. Lee JC, et al. J Biol Chem, 1996 Mar 29. PMID 8631769
  5. Mapping surface residues of eIF5A that are important for binding to the ribosome using alanine scanning mutagenesis. Barbosa NM, et al. Amino Acids, 2016 Oct. PMID 27388480, Free PMC Article

See all (89) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Rpl1b-containing ribosomes confer more efficient translation of respiration-related proteins.
    Title: Specialized ribosomes and specific ribosomal protein paralogs control translation of mitochondrial proteins.
  2. Translation of CGA codon repeats in yeast involves quality control components and ribosomal protein L1
    Title: Translation of CGA codon repeats in yeast involves quality control components and ribosomal protein L1.
  3. Data show that deletion of RPL1B had a greater effect on growth.
    Title: Eukaryotic cells producing ribosomes deficient in Rpl1 are hypersensitive to defects in the ubiquitin-proteasome system.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of ribosome IC
Inferred by Curator
more info
 PubMed 
enables structural constituent of ribosome IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cytoplasmic translation IC
Inferred by Curator
more info
 PubMed 
involved_in ribosomal large subunit export from nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic large ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
part_of large ribosomal subunit IEA
Inferred from Electronic Annotation
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
located_in ribosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ribosomal 60S subunit protein L1B
NP_011380.3
  • Ribosomal 60S subunit protein L1B; N-terminally acetylated; homologous to mammalian ribosomal protein L10A and bacterial L1; RPL1B has a paralog, RPL1A, that arose from the whole genome duplication; rpl1a rpl1b double null mutation is lethal; ribosomes containing Rpl1b are more efficient in translation of respiration-related proteins

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    254641..255294
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181000.3 → NP_011380.3  TPA: ribosomal 60S subunit protein L1B [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011380.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VU14, P0CX43, P0CX44, P53030
    UniProtKB/TrEMBL
    A0A6A5Q2N7, A6ZU48, B3LHJ3, B5VIJ6, C7GN47, C8Z8B5, G2WDW8, G2WNW5, N1P598
    Conserved Domains (1) summary
    cl00322
    Location:1 → 217
    Ribosomal_L1; Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0CX43.1
P0CX44.1

Gene LinkOut

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Other Literature Sources
Molecular Biology Databases
Research Materials
Miscellaneous