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SUA5 threonylcarbamoyladenylate synthase [ Saccharomyces cerevisiae S288C ]

Gene ID: 852707, updated on 2-Nov-2024

Summary

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Official Symbol
SUA5
Official Full Name
threonylcarbamoyladenylate synthase
Primary source
SGD:S000003137
Locus tag
YGL169W
See related
AllianceGenome:SGD:S000003137; FungiDB:YGL169W; VEuPathDB:YGL169W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables L-threonylcarbamoyladenylate synthase and single-stranded telomeric DNA binding activity. Involved in regulation of translational fidelity; tRNA threonylcarbamoyladenosine modification; and telomere maintenance. Located in mitochondrion. Human ortholog(s) of this gene implicated in Galloway-Mowat syndrome. Orthologous to human YRDC (yrdC N6-threonylcarbamoyltransferase domain containing). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See SUA5 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (186059..187339)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Spo74p Neighboring gene tRNA-Lys Neighboring gene Hur1p Neighboring gene Ca(2+)/Mn(2+)-transporting P-type ATPase PMR1 Neighboring gene Cup2p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A putative helicase, the SUA5, PMR1, tRNALys1 genes and four open reading frames have been detected in the DNA sequence of an 8.8 kb fragment of the left arm of chromosome VII of Saccharomyces cerevisiae. Klima R, et al. Yeast, 1996 Sep. PMID 8896267
  2. Loss of Elongator- and KEOPS-Dependent tRNA Modifications Leads to Severe Growth Phenotypes and Protein Aggregation in Yeast. Pollo-Oliveira L, et al. Biomolecules, 2020 Feb 18. PMID 32085421, Free PMC Article
  3. Cross kingdom functional conservation of the core universally conserved threonylcarbamoyladenosine tRNA synthesis enzymes. Thiaville PC, et al. Eukaryot Cell, 2014 Sep. PMID 25038083, Free PMC Article
  4. In vitro biosynthesis of a universal t6A tRNA modification in Archaea and Eukarya. Perrochia L, et al. Nucleic Acids Res, 2013 Feb 1. PMID 23258706, Free PMC Article
  5. Extragenic suppressors of a translation initiation defect in the cyc1 gene of Saccharomyces cerevisiae. Hampsey M, et al. Biochimie, 1991 Dec. PMID 1666843

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Loss of Elongator- and KEOPS-Dependent tRNA Modifications Leads to Severe Growth Phenotypes and Protein Aggregation in Yeast.
    Title: Loss of Elongator- and KEOPS-Dependent tRNA Modifications Leads to Severe Growth Phenotypes and Protein Aggregation in Yeast.
  2. Our results firmly established that Qri7p and Sua5p constitute the mitochondrial pathway for the biosynthesis of t(6)A and bring additional advancement in our understanding of the reaction mechanism
    Title: Cross kingdom functional conservation of the core universally conserved threonylcarbamoyladenosine tRNA synthesis enzymes.
  3. Sua5p is involved in the telomeric DNA recombination in telomerase-negative cells.
    Title: Sua5p is required for telomere recombination in Saccharomyces cerevisiae.
  4. A critical role for Sua5 and the t(6)A(37) modification in translational fidelity is revealed.
    Title: The Sua5 protein is essential for normal translational regulation in yeast.
  5. Deletion of SUA5 gene led to the loss of threonylcarbamoyladenosine.
    Title: The universal YrdC/Sua5 family is required for the formation of threonylcarbamoyladenosine in tRNA.
  6. Thus, Sua5p represents a novel ssTG DNA-binding protein and positively regulates the telomere length in vivo.
    Title: Sua5p a single-stranded telomeric DNA-binding protein facilitates telomere replication.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables L-threonylcarbamoyladenylate synthase IDA
Inferred from Direct Assay
more info
 PubMed 
enables L-threonylcarbamoyladenylate synthase IEA
Inferred from Electronic Annotation
more info
  
enables double-stranded RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotidyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables single-stranded telomeric DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables tRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of translation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of translational fidelity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of translational fidelity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA threonylcarbamoyladenosine metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tRNA threonylcarbamoyladenosine modification IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in telomere maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
threonylcarbamoyladenylate synthase
NP_011346.1
  • Protein involved in threonylcarbamoyl adenosine biosynthesis; Sua5p and Qri7p are necessary and sufficient for RNA t6A modification in vitro; null mutant lacks N6-threonylcarbamoyl adenosine (t6A) modification in the anticodon loop of ANN-decoding tRNA; member of conserved YrdC/Sua5 family; binds single-stranded telomeric DNA and null mutant has abnormal telomere length

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    186059..187339
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181034.1 → NP_011346.1  TPA: threonylcarbamoyladenylate synthase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011346.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VTY3, P32579
    UniProtKB/TrEMBL
    B5VIF9
    Conserved Domains (2) summary
    COG0009
    Location:44 → 263
    SUA5; tRNA A37 threonylcarbamoyladenosine synthetase subunit TsaC/SUA5/YrdC [Translation, ribosomal structure and biogenesis]
    pfam03481
    Location:253 → 420
    SUA5; Putative GTP-binding controlling metal-binding
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32579.1

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