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MNT2 alpha-1,3-mannosyltransferase MNT2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852635, updated on 14-Nov-2024

Summary

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Official Symbol
MNT2
Official Full Name
alpha-1,3-mannosyltransferase MNT2
Primary source
SGD:S000003226
Locus tag
YGL257C
See related
AllianceGenome:SGD:S000003226; FungiDB:YGL257C; VEuPathDB:YGL257C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables alpha-1,3-mannosyltransferase activity. Involved in protein O-linked glycosylation. Located in Golgi apparatus. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See MNT2 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (12481..14157, complement)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Vel1p Neighboring gene alcohol dehydrogenase ADH4 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mnt2p and Mnt3p of Saccharomyces cerevisiae are members of the Mnn1p family of alpha-1,3-mannosyltransferases responsible for adding the terminal mannose residues of O-linked oligosaccharides. Romero PA, et al. Glycobiology, 1999 Oct. PMID 10521541
  2. Svp26 facilitates ER exit of mannosyltransferases Mnt2 and Mnt3 in Saccharomyces cerevisiae. Tanabe Y, et al. J Gen Appl Microbiol, 2019 Sep 14. PMID 30700649
  3. BSC2 induces multidrug resistance via contributing to the formation of biofilm in Saccharomyces cerevisiae. Huang Z, et al. Cell Microbiol, 2021 Dec. PMID 34482605
  4. Clathrin light chain directs endocytosis by influencing the binding of the yeast Hip1R homologue, Sla2, to F-actin. Boettner DR, et al. Mol Biol Cell, 2011 Oct. PMID 21849475, Free PMC Article
  5. The yeast Ess1 prolyl isomerase controls Swi6 and Whi5 nuclear localization. Atencio D, et al. G3 (Bethesda), 2014 Mar 20. PMID 24470217, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables alpha-1,3-mannosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha-1,3-mannosyltransferase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables alpha-1,3-mannosyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables mannosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein O-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein O-linked glycosylation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein O-linked glycosylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cell periphery HDA PubMed 
located_in fungal-type vacuole membrane HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
alpha-1,3-mannosyltransferase MNT2
NP_011257.1
  • Mannosyltransferase; involved in adding the 4th and 5th mannose residues of O-linked glycans

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    12481..14157 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181123.1 → NP_011257.1  TPA: alpha-1,3-mannosyltransferase MNT2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011257.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VV78, P53059
    UniProtKB/TrEMBL
    A6ZTT4
    Conserved Domains (1) summary
    pfam11051
    Location:174 → 450
    Mannosyl_trans3; Mannosyltransferase putative
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53059.1

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