U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

SNF5 Snf5p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852592, updated on 14-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
SNF5
Official Full Name
Snf5p
Primary source
SGD:S000000493
Locus tag
YBR289W
See related
AllianceGenome:SGD:S000000493; FungiDB:YBR289W; VEuPathDB:YBR289W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
HAF4; SWI10; TYE4
Summary
Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in several processes, including carbon catabolite activation of transcription from RNA polymerase II promoter; double-strand break repair via homologous recombination; and positive regulation of invasive growth in response to glucose limitation. Located in cytosol and nucleus. Part of SWI/SNF complex. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 3; central nervous system cancer (multiple); rhabdoid cancer; and schwannomatosis (multiple). Orthologous to human SMARCB1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1). [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See SNF5 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (779667..782384)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Apm3p Neighboring gene Bsd2p Neighboring gene Ctp1p

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Conservation of glutamine-rich transactivation function between yeast and humans. Escher D, et al. Mol Cell Biol, 2000 Apr. PMID 10733580, Free PMC Article
  2. Constraints and consequences of the emergence of amino acid repeats in eukaryotic proteins. Chavali S, et al. Nat Struct Mol Biol, 2017 Sep. PMID 28805808, Free PMC Article
  3. Loss of Snf5 Induces Formation of an Aberrant SWI/SNF Complex. Sen P, et al. Cell Rep, 2017 Feb 28. PMID 28249160, Free PMC Article
  4. Essential roles of Snf5p in Snf-Swi chromatin remodeling in vivo. Geng F, et al. Mol Cell Biol, 2001 Jul. PMID 11390659, Free PMC Article
  5. The SNF5 protein of Saccharomyces cerevisiae is a glutamine- and proline-rich transcriptional activator that affects expression of a broad spectrum of genes. Laurent BC, et al. Mol Cell Biol, 1990 Nov. PMID 2233708, Free PMC Article

See all (178) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results indicate that the SWI/SNF chromatin-remodeling complex is recruited to DNA lesions by damage-recognition proteins to increase DNA accessibility for NER in chromatin.
    Title: Rad4-Rad23 interaction with SWI/SNF links ATP-dependent chromatin remodeling with nucleotide excision repair.
  2. This strongly suggests that the SNF5 homology domain presents species-specific functions.
    Title: Complementation analyses suggest species-specific functions of the SNF5 homology domain.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA polymerase II-specific DNA-binding transcription factor binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in carbon catabolite activation of transcription IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in chromatin remodeling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in double-strand break repair via homologous recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of invasive growth in response to glucose limitation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of SWI/SNF complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of SWI/SNF complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Snf5p
NP_009848.4
  • Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf6p; relocates to the cytosol under hypoxic conditions

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    779667..782384
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178637.4 → NP_009848.4  TPA: Snf5p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009848.4

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQT4, P18480
    UniProtKB/TrEMBL
    A6ZLM7, N1PAW8
    Conserved Domains (1) summary
    pfam04855
    Location:452 → 662
    SNF5; SNF5 / SMARCB1 / INI1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P18480.3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools