PDB1 pyruvate dehydrogenase (acetyl-transferring) subunit E1 beta [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: PDB1
Official Full Name: pyruvate dehydrogenase (acetyl-transferring) subunit E1 beta
Primary source: SGD:S000000425
Locus tag: YBR221C
See related: AllianceGenome:SGD:S000000425; FungiDB:YBR221C; VEuPathDB:YBR221C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables pyruvate dehydrogenase (acetyl-transferring) activity. Involved in acetyl-CoA biosynthetic process from pyruvate. Located in mitochondrial nucleoid. Part of pyruvate dehydrogenase complex. Human ortholog(s) of this gene implicated in pyruvate decarboxylase deficiency. Orthologous to human PDHB (pyruvate dehydrogenase E1 subunit beta). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See PDB1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 1

Sequence:: Chromosome: II; NC_001134.8 (665153..666253, complement)

Chromosome II - NC_001134.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

QTL mapping of modelled metabolic fluxes reveals gene variants impacting yeast central carbon metabolism.
Title: QTL mapping of modelled metabolic fluxes reveals gene variants impacting yeast central carbon metabolism.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables pyruvate dehydrogenase (acetyl-transferring) activity	IBA Inferred from Biological aspect of Ancestor more info
enables pyruvate dehydrogenase (acetyl-transferring) activity	IEA Inferred from Electronic Annotation more info
enables pyruvate dehydrogenase (acetyl-transferring) activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in acetyl-CoA biosynthetic process from pyruvate	IBA Inferred from Biological aspect of Ancestor more info
involved_in acetyl-CoA biosynthetic process from pyruvate	IDA Inferred from Direct Assay more info	PubMed
involved_in acetyl-CoA biosynthetic process from pyruvate	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
located_in mitochondrial nucleoid	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed
part_of pyruvate dehydrogenase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of pyruvate dehydrogenase complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: pyruvate dehydrogenase (acetyl-transferring) subunit E1 beta

NP_009780.1

EC 1.2.4.1

E1 beta subunit of the pyruvate dehydrogenase (PDH) complex; PDH is an evolutionarily conserved multi-protein complex found in mitochondria

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001134.8 Reference assembly

Range

665153..666253 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178569.1 → NP_009780.1 TPA: pyruvate dehydrogenase (acetyl-transferring) subunit E1 beta [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_009780.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VQL7, P32473

UniProtKB/TrEMBL

A6ZLG0, B3LMU1, B5VEH3, C7GMT2, D3UEW6, G2W9M4, N1P8H2

Conserved Domains (1) summary

PRK11892
Location:6 → 362

PRK11892; pyruvate dehydrogenase subunit beta; Provisional