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MSI1 Msi1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852494, updated on 2-Nov-2024

Summary

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Official Symbol
MSI1
Official Full Name
Msi1p
Primary source
SGD:S000000399
Locus tag
YBR195C
See related
AllianceGenome:SGD:S000000399; FungiDB:YBR195C; VEuPathDB:YBR195C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
CAC3
Summary
Contributes to histone binding activity. Involved in DNA replication-dependent chromatin assembly. Located in cytoplasm and nucleus. Part of CAF-1 complex. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See MSI1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (610614..611882, complement)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Med8p Neighboring gene Aim4p Neighboring gene glucose-6-phosphate isomerase Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. RIM2, MSI1 and PGI1 are located within an 8 kb segment of Saccharomyces cerevisiae chromosome II, which also contains the putative ribosomal gene L21 and a new putative essential gene with a leucine zipper motif. Démolis N, et al. Yeast, 1993 Jun. PMID 8346681
  2. Host genes that affect the target-site distribution of the yeast retrotransposon Ty1. Huang H, et al. Genetics, 1999 Apr. PMID 10101165, Free PMC Article
  3. MSI1, a negative regulator of the RAS-cAMP pathway in Saccharomyces cerevisiae. Ruggieri R, et al. Proc Natl Acad Sci U S A, 1989 Nov. PMID 2554329, Free PMC Article
  4. Ultraviolet radiation sensitivity and reduction of telomeric silencing in Saccharomyces cerevisiae cells lacking chromatin assembly factor-I. Kaufman PD, et al. Genes Dev, 1997 Feb 1. PMID 9030687
  5. The Cac2 subunit is essential for productive histone binding and nucleosome assembly in CAF-1. Mattiroli F, et al. Sci Rep, 2017 Apr 18. PMID 28418026, Free PMC Article

See all (97) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Rho5p is a target of Msi1p/Npr1p regulation and the regulatory circuit involving phosphorylation and ubiquitination.
    Title: Rho5p is involved in mediating the osmotic stress response in Saccharomyces cerevisiae, and its activity is regulated via Msi1p and Npr1p by phosphorylation and ubiquitination.
  2. Over-expression of YAK1 decreased the growth rate, but only in the presence of a functional MSI1 gene.
    Title: Mutual interdependence of MSI1 (CAC3) and YAK1 in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to histone binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA replication-dependent chromatin assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of CAF-1 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Rpd3L complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Rpd3L-Expanded complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Msi1p
NP_009754.1
  • Subunit of chromatin assembly factor I (CAF-1); chromatin assembly by CAF-1 affects multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of DNA damage checkpoint after DNA repair; chromatin dynamics during transcription; and repression of divergent noncoding transcription; Msi1p localizes to nucleus and cytoplasm and independently regulates the RAS/cAMP pathway via sequestration of Npr1p kinase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    610614..611882 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178543.1 → NP_009754.1  TPA: Msi1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009754.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQI9, P13712
    UniProtKB/TrEMBL
    B5VEE4, C7GKF4, D3UET9, G2W9J6, N1P6Y4
    Conserved Domains (3) summary
    sd00039
    Location:133 → 173
    7WD40; WD40 repeat [structural motif]
    pfam12265
    Location:21 → 88
    CAF1C_H4-bd; Histone-binding protein RBBP4 or subunit C of CAF1 complex
    cl29593
    Location:141 → 413
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P13712.1

Gene LinkOut

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