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SMY2 Smy2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852470, updated on 2-Nov-2024

Summary

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Official Symbol
SMY2
Official Full Name
Smy2p
Primary source
SGD:S000000376
Locus tag
YBR172C
See related
AllianceGenome:SGD:S000000376; FungiDB:YBR172C; VEuPathDB:YBR172C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in several processes, including endoplasmic reticulum to Golgi vesicle-mediated transport; nuclear protein quality control by the ubiquitin-proteasome system; and regulation of transcription by RNA polymerase II. Located in endoplasmic reticulum membrane. Is active in nucleus. Human ortholog(s) of this gene implicated in Parkinson's disease. Orthologous to several human genes including GIGYF1 (GRB10 interacting GYF protein 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See SMY2 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (579150..581372, complement)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene nuclear protein localization protein 4 Neighboring gene Sec63 complex subunit SEC66 Neighboring gene Ump1p Neighboring gene Swd3p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Smy2p participates in COPII vesicle formation through the interaction with Sec23p/Sec24p subcomplex. Higashio H, et al. Traffic, 2008 Jan. PMID 17973654, Free PMC Article
  2. Sequence and function analysis of a 4.3 kb fragment of Saccharomyces cerevisiae chromosome II including three open reading frames. Schaaff-Gerstenschläger I, et al. Yeast, 1993 Aug. PMID 8212898
  3. Binding specificities of the GYF domains from two Saccharomyces cerevisiae paralogs. Georgiev A, et al. Protein Eng Des Sel, 2007 Sep. PMID 17804396
  4. SMY2 and SYH1 suppress defects in ribosome biogenesis caused by ebp2 mutations. Okano A, et al. Biosci Biotechnol Biochem, 2015. PMID 25849478
  5. Distinct elongation stalls during translation are linked with distinct pathways for mRNA degradation. Veltri AJ, et al. Elife, 2022 Jul 27. PMID 35894211, Free PMC Article

See all (62) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Distinct elongation stalls during translation are linked with distinct pathways for mRNA degradation.
    Title: Distinct elongation stalls during translation are linked with distinct pathways for mRNA degradation.
  2. These results suggest that Smy2 and Syh1 may be involved in ribosome biogenesis in relation to Ebp2.
    Title: SMY2 and SYH1 suppress defects in ribosome biogenesis caused by ebp2 mutations.
  3. SESA network comprising Smy2, Eap1, Scp160 and Asc1 , specifically inhibits initiation of translation of POM34 mRNA that encodes an integral membrane protein of the nuclear pore complex
    Title: The SESA network links duplication of the yeast centrosome with the protein translation machinery.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in nuclear protein quality control by the ubiquitin-proteasome system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein-containing complex disassembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Smy2p
NP_009731.4
  • GYF domain protein; involved in COPII vesicle formation; regulates Cdc48p function in transcription stress response; interacts with the Sec23p/Sec24p subcomplex; overexpression suppresses the temperature sensitivity of a myo2 mutant; homologous to human GIGYF1 and GIGYF2; similar to S. pombe Mpd2; SMY2 has a paralog, SYH1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    579150..581372 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178520.3 → NP_009731.4  TPA: Smy2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009731.4

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQG8, P32909
    UniProtKB/TrEMBL
    G2W9H5, N1P8C3
    Conserved Domains (1) summary
    cd00072
    Location:205 → 261
    GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32909.2

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