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CCZ1 Ccz1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852428, updated on 2-Nov-2024

Summary

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Official Symbol
CCZ1
Official Full Name
Ccz1p
Primary source
SGD:S000000335
Locus tag
YBR131W
See related
AllianceGenome:SGD:S000000335; FungiDB:YBR131W; VEuPathDB:YBR131W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
CVT16
Summary
Enables phosphatidylinositol-3-phosphate binding activity; phosphatidylinositol-5-phosphate binding activity; and phosphatidylserine binding activity. Contributes to guanyl-nucleotide exchange factor activity. Involved in autophagosome maturation; protein targeting to vacuole; and vesicle docking. Located in late endosome. Part of Mon1-Ccz1 complex. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See CCZ1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (497163..499277)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Opy1p Neighboring gene She3p Neighboring gene Agp2p Neighboring gene protein arginine N-methyltransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ccz1p/Aut11p/Cvt16p is essential for autophagy and the cvt pathway. Meiling-Wesse K, et al. FEBS Lett, 2002 Aug 28. PMID 12208507
  2. The novel protein Ccz1p required for vacuolar assembly in Saccharomyces cerevisiae functions in the same transport pathway as Ypt7p. Kucharczyk R, et al. J Cell Sci, 2000 Dec. PMID 11069774
  3. The Ccz1 protein interacts with Ypt7 GTPase during fusion of multiple transport intermediates with the vacuole in S. cerevisiae. Kucharczyk R, et al. J Cell Sci, 2001 Sep. PMID 11590240
  4. The Ccz1-Mon1 protein complex is required for the late step of multiple vacuole delivery pathways. Wang CW, et al. J Biol Chem, 2002 Dec 6. PMID 12364329, Free PMC Article
  5. The yeast genes, ARL1 and CCZ1, interact to control membrane traffic and ion homeostasis. Love SL, et al. Biochem Biophys Res Commun, 2004 Jul 2. PMID 15184059

See all (83) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The authors find that Mon1-Ccz1 directly binds to Atg8, the yeast homolog of the members of the mammalian LC3 protein family.
    Title: Molecular mechanism to target the endosomal Mon1-Ccz1 GEF complex to the pre-autophagosomal structure.
  2. Guanine nucleotide exchange factor activity of the Mon1-Ccz1 complex towards Ypt7 requires the interface formed by their longin domains.
    Title: The Mon1-Ccz1 GEF activates the Rab7 GTPase Ypt7 via a longin-fold-Rab interface and association with PI3P-positive membranes.
  3. Data indicate that the Mon1-Ccz1 complex triggers endosomal maturation by activating Ypt7 on late endosomes.
    Title: The Mon1-Ccz1 complex is the GEF of the late endosomal Rab7 homolog Ypt7.
  4. These results suggest that the Ccz1p-Mon1p-Ypt7p complex is involved in fusion of transport vesicles to multiple target membranes in yeast cells.
    Title: The Saccharomyces cerevisiae protein Ccz1p interacts with components of the endosomal fusion machinery.
  5. vacuolar sorting protein Ccz1p has multiple functions in Saccharomyces cerevisiae
    Title: Multiple functions of the vacuolar sorting protein Ccz1p in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol-3-phosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol-5-phosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylserine binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in autophagosome maturation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in autophagy IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in autophagy IEA
Inferred from Electronic Annotation
more info
  
involved_in cytoplasm to vacuole targeting by the Cvt pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in macroautophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein targeting to vacuolar membrane IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein targeting to vacuolar membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein targeting to vacuole IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vacuolar transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vesicle docking IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Mon1-Ccz1 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Mon1-Ccz1 complex IEA
Inferred from Electronic Annotation
more info
  
part_of Mon1-Ccz1 complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytosol HDA PubMed 
located_in endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in late endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in multivesicular body membrane IEA
Inferred from Electronic Annotation
more info
  
located_in vacuolar membrane IEA
Inferred from Electronic Annotation
more info
  
located_in vacuole IEA
Inferred from Electronic Annotation
more info
  
located_in vesicle IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Ccz1p
NP_009689.3
  • Subunit of a heterodimeric guanine nucleotide exchange factor (GEF); subunit of the Mon1-Ccz1 GEF complex, which stimulates nucleotide exchange and activation of Ypt7p, a Rab family GTPase involved in membrane tethering and fusion events at the late endosome and vacuole; GEF activity is stimulated by membrane association and anionic phospholipids; involved in localizing Ypt7p to the vacuolar membrane; required for macroautophagy, the CVT pathway and mitophagy

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    497163..499277
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178479.3 → NP_009689.3  TPA: Ccz1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009689.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQC8, P38273
    UniProtKB/TrEMBL
    G2W9D5, N1P9H2
    Conserved Domains (1) summary
    pfam08217
    Location:6 → 703
    DUF1712; Fungal domain of unknown function (DUF1712)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38273.1

Gene LinkOut

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