TFC1 transcription factor TFIIIC subunit TFC1 [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: TFC1
Official Full Name: transcription factor TFIIIC subunit TFC1
Primary source: SGD:S000000327
Locus tag: YBR123C
See related: AllianceGenome:SGD:S000000327; FungiDB:YBR123C; VEuPathDB:YBR123C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Contributes to DNA binding activity, bending; RNA polymerase III type 1 promoter sequence-specific DNA binding activity; and RNA polymerase III type 2 promoter sequence-specific DNA binding activity. Involved in 5S class rRNA transcription by RNA polymerase III. Part of transcription factor TFIIIC complex. Orthologous to human GTF3C5 (general transcription factor IIIC subunit 5). [provided by Alliance of Genome Resources, Nov 2024]
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Chromosome II - NC_001134.8 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
contributes_to DNA binding, bending	IDA Inferred from Direct Assay more info	PubMed
contributes_to RNA polymerase III type 1 promoter sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
contributes_to RNA polymerase III type 1 promoter sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
contributes_to RNA polymerase III type 2 promoter sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
contributes_to RNA polymerase III type 2 promoter sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in 5S class rRNA transcription by RNA polymerase III	IDA Inferred from Direct Assay more info	PubMed
involved_in transcription by RNA polymerase III	IDA Inferred from Direct Assay more info	PubMed
involved_in transcription by RNA polymerase III	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transcription initiation at RNA polymerase III promoter	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of transcription factor TFIIIC complex	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription factor TFIIIC complex	IDA Inferred from Direct Assay more info	PubMed
part_of transcription factor TFIIIC complex	IEA Inferred from Electronic Annotation more info

NP_009681.3

Subunit of RNA polymerase III transcription initiation factor complex; one of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA globular domain of TFIIIC that binds DNA at the BoxA promoter sites of tRNA and similar genes; human homolog is TFIIIC-63

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The following sections contain reference sequences that belong to a specific genome build. Explain