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PFF1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852366, updated on 11-Sep-2024

Summary

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Official Symbol
PFF1
Primary source
SGD:S000000278
Locus tag
YBR074W
See related
AllianceGenome:SGD:S000000278; FungiDB:YBR074W; VEuPathDB:YBR074W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
YBR075W
Summary
Predicted to enable metal ion binding activity and metalloexopeptidase activity. Predicted to be involved in proteolysis. Located in fungal-type vacuole membrane. Orthologous to human ERMP1 (endoplasmic reticulum metallopeptidase 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (386286..389216)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene DNA-dependent ATPase RDH54 Neighboring gene Ecm8p Neighboring gene Slm4p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Assessment of inactivating stop codon mutations in forty Saccharomyces cerevisiae strains: implications for [PSI] prion- mediated phenotypes. Fitzpatrick DA, et al. PLoS One, 2011. PMID 22194885, Free PMC Article
  2. Characterization of an M28 metalloprotease family member residing in the yeast vacuole. Hecht KA, et al. FEMS Yeast Res, 2013 Aug. PMID 23679341, Free PMC Article
  3. Enhanced peptide secretion by gene disruption of CYM1, a novel protease in Saccharomyces cerevisiae. Jønson L, et al. Eur J Biochem, 2004 Dec. PMID 15606766
  4. Vps10-mediated targeting of Pep4 determines the activity of the vacuole in a substrate-dependent manner. Boutouja F, et al. Sci Rep, 2019 Jul 22. PMID 31332264, Free PMC Article
  5. The yeast vacuolar membrane proteome. Wiederhold E, et al. Mol Cell Proteomics, 2009 Feb. PMID 19001347

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metalloexopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in fungal-type vacuole membrane HDA PubMed 
located_in fungal-type vacuole membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in vacuolar membrane IEA
Inferred from Electronic Annotation
more info
  
located_in vacuole IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Pff1p
NP_009630.3
  • Multi-spanning vacuolar membrane protease; glycosylated transmembrane protein bearing homology to M28 family of metalloproteases; has lumenal-facing protease domain; proposed role in vacuole physiology; targeted to vacuole via AP-3 pathway

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    386286..389216
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178422.2 → NP_009630.3  TPA: Pff1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009630.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQ74, P38244, P38245, Q86ZS2
    UniProtKB/TrEMBL
    G2W980, N1P8C2
    Conserved Domains (2) summary
    cd03875
    Location:50 → 354
    M28_Fxna_like; M28 Zn-peptidase Endoplasmic reticulum metallopeptidase 1
    cl02291
    Location:366 → 443
    DUF2189; Predicted integral membrane protein (DUF2189)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38244.3

Gene LinkOut

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