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MUM2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852348, updated on 11-Sep-2024

Summary

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Official Symbol
MUM2
Primary source
SGD:S000000261
Locus tag
YBR057C
See related
AllianceGenome:SGD:S000000261; FungiDB:YBR057C; VEuPathDB:YBR057C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in mRNA methylation; negative regulation of pseudohyphal growth; and premeiotic DNA replication. Located in cytoplasm. Part of RNA N6-methyladenosine methyltransferase complex. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (352193..353293, complement)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene tRNA-Gln Neighboring gene Mnc1p Neighboring gene ubiquitin-specific protease UBP14 Neighboring gene Tsc3p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The isolation and genetic analysis of sporulation-deficient mutants in Saccharomyces cerevisiae. Tsuboi M. Mol Gen Genet, 1983. PMID 6350825
  2. Widespread Prion-Based Control of Growth and Differentiation Strategies in Saccharomyces cerevisiae. Itakura AK, et al. Mol Cell, 2020 Jan 16. PMID 31757756, Free PMC Article
  3. RNA methylation by the MIS complex regulates a cell fate decision in yeast. Agarwala SD, et al. PLoS Genet, 2012. PMID 22685417, Free PMC Article
  4. The Saccharomyces cerevisiae MUM2 gene interacts with the DNA replication machinery and is required for meiotic levels of double strand breaks. Davis L, et al. Genetics, 2001 Mar. PMID 11238403, Free PMC Article
  5. High-resolution mapping reveals a conserved, widespread, dynamic mRNA methylation program in yeast meiosis. Schwartz S, et al. Cell, 2013 Dec 5. PMID 24269006, Free PMC Article

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in meiotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of pseudohyphal growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in premeiotic DNA replication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sporulation resulting in formation of a cellular spore IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of RNA N6-methyladenosine methyltransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of RNA N6-methyladenosine methyltransferase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Mum2p
NP_009613.1
  • Protein essential for meiotic DNA replication and sporulation; cytoplasmic protein; subunit of the MIS complex which controls mRNA methylation during during the induction of sporulation; also interacts with Orc2p, which is a component of the origin recognition complex

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    352193..353293 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178405.1 → NP_009613.1  TPA: Mum2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009613.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQ56, P38236
    UniProtKB/TrEMBL
    A6ZL01, B3LN92, B5VE22, C7GSU3, D3UEF4, G2W962, N1P6H8
    Conserved Domains (1) summary
    pfam17098
    Location:189 → 356
    Wtap; WTAP/Mum2p family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38236.1

Gene LinkOut

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