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PRP6 U4/U6-U5 snRNP complex subunit PRP6 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852344, updated on 18-Sep-2024

Summary

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Official Symbol
PRP6
Official Full Name
U4/U6-U5 snRNP complex subunit PRP6
Primary source
SGD:S000000259
Locus tag
YBR055C
See related
AllianceGenome:SGD:S000000259; FungiDB:YBR055C; VEuPathDB:YBR055C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
RNA6; TSM7269
Summary
Involved in mRNA splicing, via spliceosome. Part of U4/U6 snRNP and U4/U6 x U5 tri-snRNP complex. Human ortholog(s) of this gene implicated in retinitis pigmentosa 60. Orthologous to human PRPF6 (pre-mRNA processing factor 6). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See PRP6 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (344602..347301, complement)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Yro2p Neighboring gene tRNA-Leu Neighboring gene 17-beta-hydroxysteroid dehydrogenase-like protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The biochemical defects of prp4-1 and prp6-1 yeast splicing mutants reveal that the PRP6 protein is required for the accumulation of the [U4/U6.U5] tri-snRNP. Galisson F, et al. Nucleic Acids Res, 1993 Apr 11. PMID 8479905, Free PMC Article
  2. Some cis- and trans-acting mutants for splicing target pre-mRNA to the cytoplasm. Legrain P, et al. Cell, 1989 May 19. PMID 2655924
  3. Isolation of S. cerevisiae snRNPs: comparison of U1 and U4/U6.U5 to their human counterparts. Fabrizio P, et al. Science, 1994 Apr 8. PMID 8146658
  4. The yeast PRP6 gene encodes a U4/U6 small nuclear ribonucleoprotein particle (snRNP) protein, and the PRP9 gene encodes a protein required for U2 snRNP binding. Abovich N, et al. Mol Cell Biol, 1990 Dec. PMID 2147224, Free PMC Article
  5. The molecular characterization of PRP6 and PRP9 yeast genes reveals a new cysteine/histidine motif common to several splicing factors. Legrain P, et al. EMBO J, 1990 Sep. PMID 2118103, Free PMC Article

See all (67) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in RNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA splicing, via spliceosome IEA
Inferred from Electronic Annotation
more info
  
involved_in spliceosomal tri-snRNP complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of U4/U6 x U5 tri-snRNP complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U4/U6 x U5 tri-snRNP complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
U4/U6-U5 snRNP complex subunit PRP6
NP_009611.1
  • Splicing factor; component of the U4/U6-U5 snRNP complex

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    344602..347301 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178403.1 → NP_009611.1  TPA: U4/U6-U5 snRNP complex subunit PRP6 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009611.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQ54, P19735
    UniProtKB/TrEMBL
    A6ZKZ8, B3LN94, D3UEF0, N1P9D6
    Conserved Domains (4) summary
    TIGR02917
    Location:609 → 831
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:668 → 696
    TPR; TPR repeat [structural motif]
    pfam06424
    Location:11 → 131
    PRP1_N; PRP1 splicing factor, N-terminal
    cl26712
    Location:201 → 370
    U3_assoc_6; U3 small nucleolar RNA-associated protein 6
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P19735.1

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