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RKM3 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852318, updated on 11-Sep-2024

Summary

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Official Symbol
RKM3
Primary source
SGD:S000000234
Locus tag
YBR030W
See related
AllianceGenome:SGD:S000000234; FungiDB:YBR030W; VEuPathDB:YBR030W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables protein-lysine N-methyltransferase activity. Involved in peptidyl-lysine monomethylation. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (298292..299950)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene putative protein kinase YPK3 Neighboring gene phosphatidate cytidylyltransferase Neighboring gene ribosomal 60S subunit protein L4A Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Reduction of CDP-diacylglycerol synthase activity results in the excretion of inositol by Saccharomyces cerevisiae. Shen H, et al. J Biol Chem, 1996 Nov 15. PMID 8910557
  2. A novel SET domain methyltransferase in yeast: Rkm2-dependent trimethylation of ribosomal protein L12ab at lysine 10. Porras-Yakushi TR, et al. J Biol Chem, 2006 Nov 24. PMID 17005568
  3. Identification of two SET domain proteins required for methylation of lysine residues in yeast ribosomal protein Rpl42ab. Webb KJ, et al. J Biol Chem, 2008 Dec 19. PMID 18957409, Free PMC Article
  4. Stoichiometry of Saccharomyces cerevisiae lysine methylation: insights into non-histone protein lysine methyltransferase activity. Hart-Smith G, et al. J Proteome Res, 2014 Mar 7. PMID 24517342
  5. Ribosomal protein methyltransferases in the yeast Saccharomyces cerevisiae: Roles in ribosome biogenesis and translation. Al-Hadid Q, et al. Biochem Biophys Res Commun, 2016 Feb 12. PMID 26801560, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-lysine N-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-lysine N-methyltransferase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables protein-lysine N-methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in peptidyl-lysine monomethylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-lysine monomethylation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in peptidyl-lysine monomethylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein-lysine N-methyltransferase
NP_009586.1
  • Ribosomal lysine methyltransferase; specific for monomethylation of Rpl42ap and Rpl42bp (lysine 40); nuclear SET domain containing protein; relocalizes to the cytosol in response to hypoxia

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    298292..299950
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178378.1 → NP_009586.1  TPA: protein-lysine N-methyltransferase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009586.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQ31, P38222
    UniProtKB/TrEMBL
    C7GM23
    Conserved Domains (1) summary
    cd10527
    Location:27 → 349
    SET_LSMT; SET domain found in Rubisco large subunit methyltransferase (LSMT) and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38222.1

Gene LinkOut

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