FUR4 uracil permease [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: FUR4
Official Full Name: uracil permease
Primary source: SGD:S000000225
Locus tag: YBR021W
See related: AllianceGenome:SGD:S000000225; FungiDB:YBR021W; VEuPathDB:YBR021W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables uracil:monoatomic cation symporter activity. Involved in transmembrane transport and uracil transport. Located in eisosome and plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
NEW: Try the new Gene table
Try the new Transcript table

Chromosome II - NC_001134.8 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Plasma membrane tension regulates eisosome structure and function.
Title: Plasma membrane tension regulates eisosome structure and function.
Conformation-sensing domain regulates Fur4 substrate-dependent degradation.
Title: Quality control and substrate-dependent downregulation of the nutrient transporter Fur4.
GPI-anchored proteins are required for the recruitment of membrane proteins Tat2p and Fur4p to the plasma membrane via detergent-resistant membranes.
Title: Glycosylphosphatidylinositol-anchored proteins are required for the transport of detergent-resistant microdomain-associated membrane proteins Tat2p and Fur4p.
During heat stress, sphingolipids signal turnover of the uracil permease, Fur4.
Title: Slm1 and slm2 are novel substrates of the calcineurin phosphatase required for heat stress-induced endocytosis of the yeast uracil permease.
analysis of long-term stability of the subdomains of Can1p: Fur4p (another H+ symporter) and Sur7p (a protein of unknown function) occupy the Can1p subdomain
Title: Distribution of Can1p into stable domains reflects lateral protein segregation within the plasma membrane of living S. cerevisiae cells.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables nucleobase transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables uracil:monoatomic cation symporter activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in nitrogen compound transport	IEA Inferred from Electronic Annotation more info
involved_in nucleobase transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in uracil transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in uracil transport	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cell periphery	HDA more info	PubMed
located_in eisosome	IDA Inferred from Direct Assay more info	PubMed
located_in fungal-type vacuole	HDA more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

NP_009577.1

Plasma membrane localized uracil permease; expression is tightly regulated by uracil levels and environmental cues; conformational alterations induced by unfolding or substrate binding result in Rsp5p-mediated ubiquitination and degradation

NEW Try the new Transcript table

The following sections contain reference sequences that belong to a specific genome build. Explain