HIR1 Hir1p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: HIR1
Official Full Name: Hir1p
Primary source: SGD:S000000104
Locus tag: YBL008W
See related: AllianceGenome:SGD:S000000104; FungiDB:YBL008W; VEuPathDB:YBL008W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables transcription corepressor activity. Contributes to DNA binding activity and nucleosome binding activity. Involved in DNA replication-independent chromatin assembly; negative regulation of transcription, DNA-templated; and transcription elongation from RNA polymerase II promoter. Located in chromosome, centromeric region. Part of HIR complex. Orthologous to human HIRA (histone cell cycle regulator). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See HIR1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 1

Sequence:: Chromosome: II; NC_001134.8 (209653..212175)

Chromosome II - NC_001134.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

our study identified a novel mechanism by which H3K4me3 antagonizes the HIR/Asf1/Rtt106 repressor complex to promote histone gene expression and extend chronological life span.
Title: Set1-catalyzed H3K4 trimethylation antagonizes the HIR/Asf1/Rtt106 repressor complex to promote histone gene expression and chronological life span.
inactivation of the negative regulatory system by deletion of the HIR1 gene relieved the dependence of HTA1-HTB1 transcription on the mitotic Clb1/Cb2 cyclins
Title: The mitotic Clb cyclins are required to alleviate HIR-mediated repression of the yeast histone genes at the G1/S transition.
nucleosome shielding is the primary means to maintain promoter fidelity, and histone replacement is most efficiently mediated in yeast cells by a HIR/Asf1/H3-H4/Rtt106 pathway.
Title: The replication-independent histone H3-H4 chaperones HIR, ASF1, and RTT106 co-operate to maintain promoter fidelity.
Asf1 and HIR are important for histone deposition but each has a different effect on histone exchange
Title: Histone chaperones regulate histone exchange during transcription.
overexpression of HIR1 in the Kllsm4Delta1 mutant prevented rapid cell death during aging, reduced nuclei fragmentation & increased resistance to H2O2; expression of histone genes is lowered in the mutant indicating a relationship between HIR1 & apoptosis
Title: HIR1, the co-repressor of histone gene transcription of Saccharomyces cerevisiae, acts as a multicopy suppressor of the apoptotic phenotypes of the LSM4 mRNA degradation mutant.
Restoration of silencing to CAF-1 subunit cac1 Delta cells requires both Hir1 and Asf1
Title: Regulation of histone deposition proteins Asf1/Hir1 by multiple DNA damage checkpoint kinases in Saccharomyces cerevisiae.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
contributes_to DNA binding	IDA Inferred from Direct Assay more info	PubMed
contributes_to nucleosome binding	IBA Inferred from Biological aspect of Ancestor more info
contributes_to nucleosome binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables transcription corepressor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in chromatin organization	IDA Inferred from Direct Assay more info	PubMed
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase III	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of transcription by RNA polymerase III	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in transcription elongation by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
part_of HIR complex	IBA Inferred from Biological aspect of Ancestor more info
part_of HIR complex	IDA Inferred from Direct Assay more info	PubMed
part_of HIR complex	IPI Inferred from Physical Interaction more info	PubMed
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in chromosome, centromeric region	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome, centromeric region	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Hir1p

NP_009545.2

Subunit of the HIR complex; HIR is a nucleosome assembly complex involved in regulation of histone gene transcription; contributes to nucleosome formation, heterochromatic gene silencing, and formation of functional kinetochores

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001134.8 Reference assembly

Range

209653..212175

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178248.2 → NP_009545.2 TPA: Hir1p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_009545.2

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VPZ2, P32479

UniProtKB/TrEMBL

A6ZKU0, G2W901

Conserved Domains (3) summary

sd00039
Location:20 → 66

7WD40; WD40 repeat [structural motif]

pfam07569
Location:735 → 807

Hira; TUP1-like enhancer of split

cl29593
Location:20 → 384

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...