FMT1 methionyl-tRNA formyltransferase [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: FMT1
Official Full Name: methionyl-tRNA formyltransferase
Primary source: SGD:S000000109
Locus tag: YBL013W
See related: AllianceGenome:SGD:S000000109; FungiDB:YBL013W; VEuPathDB:YBL013W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables methionyl-tRNA formyltransferase activity. Involved in conversion of methionyl-tRNA to N-formyl-methionyl-tRNA. Located in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 15 and nuclear type mitochondrial complex I deficiency 27. Orthologous to human MTFMT (mitochondrial methionyl-tRNA formyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome II - NC_001134.8 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables methionyl-tRNA formyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables methionyl-tRNA formyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables methionyl-tRNA formyltransferase activity	IEA Inferred from Electronic Annotation more info
enables methionyl-tRNA formyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in conversion of methionyl-tRNA to N-formyl-methionyl-tRNA	IBA Inferred from Biological aspect of Ancestor more info
involved_in conversion of methionyl-tRNA to N-formyl-methionyl-tRNA	IDA Inferred from Direct Assay more info	PubMed
involved_in conversion of methionyl-tRNA to N-formyl-methionyl-tRNA	IEA Inferred from Electronic Annotation more info
involved_in conversion of methionyl-tRNA to N-formyl-methionyl-tRNA	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in translation	IEA Inferred from Electronic Annotation more info
involved_in translational initiation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

NP_009540.2

Methionyl-tRNA formyltransferase; catalyzes formylation of mitochondria initiator Met-tRNA and residual cytosolic Met-tRNA due to inefficient translocation into the mitochondrial matrix; starvation or stationary phase entry increases Gcn2p phosphorylation-mediated cytosolic retention of Fmt1p, enhancing N-terminal protein formylation and ultimately N-end rule pathway mediated destruction that involves the Psh1p ubiquitin ligase; potential Cdc28p substrate

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