ACH1 acetyl-CoA hydrolase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: ACH1
Official Full Name: acetyl-CoA hydrolase
Primary source: SGD:S000000111
Locus tag: YBL015W
See related: AllianceGenome:SGD:S000000111; FungiDB:YBL015W; VEuPathDB:YBL015W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables acetate CoA-transferase activity and acetyl-CoA hydrolase activity. Involved in acetate metabolic process. Located in cytosol and mitochondrion. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ACH1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 1

Sequence:: Chromosome: II; NC_001134.8 (194122..195702)

Chromosome II - NC_001134.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mitochondrial Ach1 can convert acetyl-CoA in this compartment into acetate, which crosses the mitochondrial membrane before being converted into acetyl-CoA in the cytosol.
Title: Ach1 is involved in shuttling mitochondrial acetyl units for cytosolic C2 provision in Saccharomyces cerevisiae lacking pyruvate decarboxylase.
Ach1 is involved in mitochondrial acetate detoxification.
Title: Re-characterisation of Saccharomyces cerevisiae Ach1p: fungal CoA-transferases are involved in acetic acid detoxification.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables acetate CoA-transferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables acetate CoA-transferase activity	IDA Inferred from Direct Assay more info	PubMed
enables acetate CoA-transferase activity	IEA Inferred from Electronic Annotation more info
enables acetyl-CoA hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables acetyl-CoA hydrolase activity	IDA Inferred from Direct Assay more info	PubMed
enables acetyl-CoA hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in acetate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in acetate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in acetate metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: acetyl-CoA hydrolase

NP_009538.1

EC 3.1.2.1

Protein with CoA transferase activity; particularly for CoASH transfer from succinyl-CoA to acetate; has minor acetyl-CoA-hydrolase activity; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001134.8 Reference assembly

Range

194122..195702

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178255.1 → NP_009538.1 TPA: acetyl-CoA hydrolase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_009538.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VPY5, P32316

UniProtKB/TrEMBL

A6ZKT3, B3LNF3, C7GX95, C8Z3Y1, G2W8Z4, N1P7F3

Conserved Domains (1) summary

COG0427
Location:6 → 519

ACH1; Acyl-CoA hydrolase [Energy production and conversion]