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LSM2 Sm-like protein LSM2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852255, updated on 3-Nov-2024

Summary

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Official Symbol
LSM2
Official Full Name
Sm-like protein LSM2
Primary source
SGD:S000000122
Locus tag
YBL026W
See related
AllianceGenome:SGD:S000000122; FungiDB:YBL026W; VEuPathDB:YBL026W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
SMX5; SNP3
Summary
Contributes to RNA binding activity. Involved in mRNA splicing, via spliceosome. Located in P-body and nucleolus. Part of Lsm1-7-Pat1 complex; sno(s)RNA-containing ribonucleoprotein complex; and spliceosomal snRNP complex. Orthologous to human LSM2 (LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See LSM2 in Genome Data Viewer
Location:
chromosome: II
Exon count:
2
Sequence:
Chromosome: II; NC_001134.8 (170623..171038)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ribosomal 60S subunit protein L19B Neighboring gene Rrn10p Neighboring gene tRNA (cytosine-C5-)-methyltransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. An extended RNA binding site for the yeast branch point-binding protein and the role of its zinc knuckle domains in RNA binding. Garrey SM, et al. J Biol Chem, 2006 Sep 15. PMID 16861232
  2. Crystal structure of Lsm3 octamer from Saccharomyces cerevisiae: implications for Lsm ring organisation and recruitment. Naidoo N, et al. J Mol Biol, 2008 Apr 11. PMID 18329667
  3. The Rpb7p subunit of yeast RNA polymerase II plays roles in the two major cytoplasmic mRNA decay mechanisms. Lotan R, et al. J Cell Biol, 2007 Sep 24. PMID 17875743, Free PMC Article
  4. The RNA polymerase II subunit Rpb4p mediates decay of a specific class of mRNAs. Lotan R, et al. Genes Dev, 2005 Dec 15. PMID 16357218, Free PMC Article
  5. Lsm proteins are required for normal processing of pre-tRNAs and their efficient association with La-homologous protein Lhp1p. Kufel J, et al. Mol Cell Biol, 2002 Jul. PMID 12077351, Free PMC Article

See all (97) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The C-terminal helix of Lsm2 intreacting with the structure of the C-terminal domain of Pat1 suggests a potential mechanism for RNA binding that involves the helix and loop faces of the Lsm1-7 ring.
    Title: Lsm2 and Lsm3 bridge the interaction of the Lsm1-7 complex with Pat1 for decapping activation.
  2. an Lsm2-Lsm7 protein complex resides in nucleoli, contributing to the biogenesis or function of specific snoRNAs
    Title: An Lsm2-Lsm7 complex in Saccharomyces cerevisiae associates with the small nucleolar RNA snR5.
  3. Lsm2-8p complex normally targets nuclear RNA substrates for decapping
    Title: Nuclear pre-mRNA decapping and 5' degradation in yeast require the Lsm2-8p complex.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA splicing, via spliceosome IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Lsm1-7-Pat1 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Lsm1-7-Pat1 complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in P-body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in P-body IDA
Inferred from Direct Assay
more info
 PubMed 
part_of U4/U6 x U5 tri-snRNP complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U4/U6 x U5 tri-snRNP complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of U6 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U6 snRNP IDA
Inferred from Direct Assay
more info
 PubMed 
part_of catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of precatalytic spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
  
part_of sno(s)RNA-containing ribonucleoprotein complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Sm-like protein LSM2
NP_009527.1
  • Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    170623..171038
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178266.1 → NP_009527.1  TPA: Sm-like protein LSM2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009527.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VPX4, P38203
    UniProtKB/TrEMBL
    A6ZKS2, B3LNG3, C7GX84, C8Z3X0, N1P9R1
    Conserved Domains (1) summary
    cd01725
    Location:2 → 90
    LSm2; Like-Sm protein 2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38203.1

Gene LinkOut

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