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PRE7 proteasome core particle subunit beta 6 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852239, updated on 2-Nov-2024

Summary

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Official Symbol
PRE7
Official Full Name
proteasome core particle subunit beta 6
Primary source
SGD:S000000137
Locus tag
YBL041W
See related
AllianceGenome:SGD:S000000137; FungiDB:YBL041W; VEuPathDB:YBL041W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
PRS3
Summary
Involved in proteasomal ubiquitin-independent protein catabolic process and proteasome-mediated ubiquitin-dependent protein catabolic process. Located in cytosol and nucleus. Part of proteasome core complex, beta-subunit complex. Orthologous to human PSMB1 (proteasome 20S subunit beta 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See PRE7 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (141247..141972)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Ecm13p Neighboring gene uridine permease Neighboring gene Erd2p Neighboring gene Min6p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. PRS3 encoding an essential subunit of yeast proteasomes homologous to mammalian proteasome subunit C5. Lee DH, et al. Biochem Biophys Res Commun, 1992 Jan 31. PMID 1734860
  2. Genetic screen identifies adaptive aneuploidy as a key mediator of ER stress resistance in yeast. Beaupere C, et al. Proc Natl Acad Sci U S A, 2018 Sep 18. PMID 30185560, Free PMC Article
  3. Expression attenuation as a mechanism of robustness against gene duplication. Ascencio D, et al. Proc Natl Acad Sci U S A, 2021 Feb 9. PMID 33526669, Free PMC Article
  4. The catalytic sites of 20S proteasomes and their role in subunit maturation: a mutational and crystallographic study. Groll M, et al. Proc Natl Acad Sci U S A, 1999 Sep 28. PMID 10500111, Free PMC Article
  5. Development of a novel cross-linking strategy for fast and accurate identification of cross-linked peptides of protein complexes. Kao A, et al. Mol Cell Proteomics, 2011 Jan. PMID 20736410, Free PMC Article

See all (73) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in proteasomal ubiquitin-independent protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proteasomal ubiquitin-independent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis involved in protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of proteasome complex IEA
Inferred from Electronic Annotation
more info
  
part_of proteasome core complex IEA
Inferred from Electronic Annotation
more info
  
part_of proteasome core complex, beta-subunit complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of proteasome core complex, beta-subunit complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of proteasome core complex, beta-subunit complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
proteasome core particle subunit beta 6
NP_009512.1
  • Beta 6 subunit of the 20S proteasome

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    141247..141972
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178281.1 → NP_009512.1  TPA: proteasome core particle subunit beta 6 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009512.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VPV7, P23724
    UniProtKB/TrEMBL
    A6ZKQ5, B3LNI0, B5VDU3, C7GNC1, C8Z3Q6, G2W8W6, N1P9Q3
    Conserved Domains (1) summary
    cd03757
    Location:21 → 241
    proteasome_beta_type_1; proteasome beta type-1 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P23724.1

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