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SHP1 protein phosphatase regulator SHP1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852222, updated on 3-Nov-2024

Summary

Official Symbol
SHP1
Official Full Name
protein phosphatase regulator SHP1
Primary source
SGD:S000000154
Locus tag
YBL058W
See related
AllianceGenome:SGD:S000000154; FungiDB:YBL058W; VEuPathDB:YBL058W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
UBX1
Summary
Enables K48-linked polyubiquitin modification-dependent protein binding activity and protein phosphatase regulator activity. Involved in several processes, including macroautophagy; proteasomal protein catabolic process; and sister chromatid biorientation. Located in cytosol and nucleus. Orthologous to several human genes including UBXN2B (UBX domain protein 2B). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

See SHP1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (111437..112708)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Cmc2p Neighboring gene Iai11p Neighboring gene aminoacyl-tRNA hydrolase Neighboring gene type 2C protein phosphatase PTC3

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables K48-linked polyubiquitin modification-dependent protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein phosphatase regulator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables ubiquitin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in ERAD pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in Golgi organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in ascospore formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in autophagosome assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glycogen metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in membrane fusion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in nuclear membrane reassembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in piecemeal microautophagy of the nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sister chromatid biorientation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein phosphatase regulator SHP1
NP_009495.1
  • Substrate adaptor for Cdc48p; ubiquitin regulatory X (UBX) and Ub-associated (UBA) domain-containing protein that acts as a substrate recruiting cofactor; K48-specific Ub chain binding protein involved in ER-associated degradation (ERAD); positively regulates Glc7p protein phosphatase activity to promote growth and mitotic progression in complex with Cdc48p; regulated by nuclear Ub-dependent degradation (INMAD pathway) independent of the Asi and Doa10 complexes; homolog of human p47 (NSFL1C)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    111437..112708
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178298.1NP_009495.1  TPA: protein phosphatase regulator SHP1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009495.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VPU2, E9P8S9, P34223
    UniProtKB/TrEMBL
    A6ZKP1, B3LNJ3, C7GNA7
    Conserved Domains (3) summary
    smart00553
    Location:231323
    SEP; Domain present in Saccharomyces cerevisiae Shp1, Drosophila melanogaster eyes closed gene (eyc), and vertebrate p47
    cd14351
    Location:641
    UBA_Ubx1_like; UBA-like domain found in yeast UBX domain-containing protein 1 (Ubx1) and similar proteins
    cd01770
    Location:350421
    UBX_UBXN2; Ubiquitin regulatory domain X (UBX) found in UBX domain-containing proteins UBXN2A, UBXN2B, NSFL1C/UBXN2C, and similar proteins