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AAR2 U5 snRNP complex subunit AAR2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852205, updated on 18-Sep-2024

Summary

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Official Symbol
AAR2
Official Full Name
U5 snRNP complex subunit AAR2
Primary source
SGD:S000000170
Locus tag
YBL074C
See related
AllianceGenome:SGD:S000000170; FungiDB:YBL074C; VEuPathDB:YBL074C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in spliceosomal tri-snRNP complex assembly. Part of U5 snRNP. Orthologous to human AAR2 (AAR2 splicing factor). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See AAR2 in Genome Data Viewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (86722..87789, complement)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene isoleucine--tRNA ligase ILS1 Neighboring gene Hsp70 family ATPase SSA3 Neighboring gene ncRNA Neighboring gene ribosomal 40S subunit protein S8A

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. AAR2, a gene for splicing pre-mRNA of the MATa1 cistron in cell type control of Saccharomyces cerevisiae. Nakazawa N, et al. Mol Cell Biol, 1991 Nov. PMID 1922071, Free PMC Article
  2. Crystallization and biochemical characterization of the human spliceosomal Aar2-Prp8(RNaseH) complex. Santos K, et al. Acta Crystallogr F Struct Biol Commun, 2015 Nov. PMID 26527271, Free PMC Article
  3. Crystal structure of Prp8 reveals active site cavity of the spliceosome. Galej WP, et al. Nature, 2013 Jan 31. PMID 23354046, Free PMC Article
  4. Mechanism for Aar2p function as a U5 snRNP assembly factor. Weber G, et al. Genes Dev, 2011 Aug 1. PMID 21764848, Free PMC Article
  5. Structural basis of Brr2-Prp8 interactions and implications for U5 snRNP biogenesis and the spliceosome active site. Nguyen TH, et al. Structure, 2013 Jun 4. PMID 23727230, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Aar2p regulates both protein and RNA binding to Prp8p during U5 snRNP assembly
    Title: Structural basis for dual roles of Aar2p in U5 snRNP assembly.
  2. Prp8 interaction sites with Aar2 protein
    Title: Prp8p dissection reveals domain structure and protein interaction sites.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in spliceosomal tri-snRNP complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spliceosomal tri-snRNP complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of U5 snRNP IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
U5 snRNP complex subunit AAR2
NP_009479.1
  • Component of the U5 snRNP complex; required for splicing of U3 precursors; originally described as a splicing factor specifically required for splicing pre-mRNA of the MATa1 cistron

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    86722..87789 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178314.1 → NP_009479.1  TPA: U5 snRNP complex subunit AAR2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009479.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VPS8, P32357
    UniProtKB/TrEMBL
    A6ZKM7, B3LNK7, B5VDR6, C7GK59, C8Z3R9, G2W8T7, N1P8G2
    Conserved Domains (2) summary
    cd13778
    Location:175 → 313
    Aar2_C; C-terminal domain of Aar2, a U5 small nuclear ribonucleoprotein particle assembly factor
    pfam05282
    Location:3 → 283
    AAR2; AAR2 protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32357.1

Gene LinkOut

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