U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

SRO77 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852168, updated on 11-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
SRO77
Primary source
SGD:S000000202
Locus tag
YBL106C
See related
AllianceGenome:SGD:S000000202; FungiDB:YBL106C; VEuPathDB:YBL106C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
SNI2; SOP2
Summary
Predicted to enable GTPase activator activity; myosin II binding activity; and syntaxin binding activity. Involved in Golgi to plasma membrane transport and exocytosis. Located in plasma membrane. Orthologous to several human genes including LLGL1 (LLGL scribble cell polarity complex component 1); LLGL2 (LLGL scribble cell polarity complex component 2); and STXBP5 (syntaxin binding protein 5). [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (10847..13879, complement)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene tRNA-Leu Neighboring gene Mix23p Neighboring gene protein kinase C Neighboring gene Sea4p

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Complementation of temperature tolerance by rat Rgl-1 recessive oncogene in the absence of Saccharomyces cerevisiae Sop genes. Kim YK, et al. Oncol Rep, 2004 Nov. PMID 15492800
  2. Disruption of protein-protein interaction in the Mgl-1 oncoprotein. Kim YS, et al. Oncol Rep, 2006 Oct. PMID 16969496
  3. Yeast lacking the SRO7/SOP1-encoded tumor suppressor homologue show increased susceptibility to apoptosis-like cell death on exposure to NaCl stress. Wadskog I, et al. Mol Biol Cell, 2004 Mar. PMID 14718573, Free PMC Article
  4. Functional and expression analyses of mgl-1, a mouse orthologue of lethal giant larvae recessive oncogene. Kim YS, et al. Int J Oncol, 2003 Dec. PMID 14612921
  5. WD-40 repeat containing rat lethal giant larvae recessive oncogene, but not m-tomosyn, restores the salt sensitivity in Saccharomyces cerevisiae. Kim YS, et al. Int J Oncol, 2003 Jul. PMID 12792798

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results suggested that the tumour suppressor homologue SRO7/SRO77 regulated cell proliferation and yeast colony development via the Rho1-Tor1 pathway.
    Title: Sro7 and Sro77, the yeast homologues of the Drosophila lethal giant larvae (Lgl), regulate cell proliferation via the Rho1-Tor1 pathway.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables myosin II binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables syntaxin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in Golgi to plasma membrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Golgi to plasma membrane transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in Golgi to plasma membrane transport IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in exocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in exocytosis IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cellular bud neck HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
putative Rab GTPase-binding protein SRO77
NP_009444.2
  • Protein with roles in exocytosis and cation homeostasis; functions in docking and fusion of post-Golgi vesicles with plasma membrane; regulates cell proliferation and colony development via the Rho1-Tor1 pathway; interacts with SNARE protein Sec9p; homolog of Drosophila lethal giant larvae tumor suppressor; SRO77 has a paralog, SRO7, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    10847..13879 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178346.2 → NP_009444.2  TPA: putative Rab GTPase-binding protein SRO77 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009444.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VPP7, P38163
    UniProtKB/TrEMBL
    B5VDN9, C7GSD9, N1P8F1
    Conserved Domains (3) summary
    sd00039
    Location:88 → 122
    7WD40; WD40 repeat [structural motif]
    pfam08596
    Location:514 → 916
    Lgl_C; Lethal giant larvae(Lgl) like, C-terminal
    pfam17005
    Location:48 → 151
    WD40_like; WD40-like domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38163.2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools